What controls the balance between #cartilage and #BoneFormation?
ST3GAL1-associated α-2,3 sialylation regulates chondrocyte and #osteoblast differentiation, with its loss impairing growth plate maturation & reducing bone mass.
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...

Why bone formation fails remains unclear.
This study identifies JAM3 as a key regulator that stabilizes #LRP5, promotes #osteoblast formation, and preserves bone mass, revealing a promising target for skeletal disorders.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...