Multiple sclerosis (MS) is a persistent immune-mediated condition marked by neuroinflammation, demyelination, and ongoing neurological impairment. Although there have been advancements in therapies aimed at modifying the disease, signifi...
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Oligodendrocyte precursor cells (OPCs) are abundant progenitor cells in the central nervous system. Unlike mature oligodendrocytes, OPCs form functional synapses with neurons and respond to both glutamatergic and GABAergic signals. Gluta...
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Abstract Multiple sclerosis (MS) is a debilitating demyelinating disease of the central nervous system (CNS) in which progressive neurological disability is closely linked to the failure of endogenous remyelination. Reactive astrocytes a...
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Twenty-one-day-old Wistar rats were fed a diet containing 0.6% cuprizone for 2 weeks. Studies carried out after withdrawal of cuprizone showed histological evidences of marked demyelination in the corpus callosum. Biochemical studies of ...
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The current study presents two different approaches with a view to elucidating the interaction between thyroid hormones (TH) and apo-transferrin (aTf) and their role in myelination and remyelination. First, in vitro assays were conducted...
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Myelination is a concerted mechanism tightly regulated in the brain. Although several factors are known to participate during this process, the complete sequence of events is far from being fully elucidated. Separate effects of apotransf...
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Thyroid hormones (THs) and transferrin (Tf) are factors capable of favoring myelination due to their positive effects on oligodendroglial cell (OLG) differentiation. The first notion of a combined effect of apotransferrin (aTf) and TH em...
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Oligodendroglial damage and demyelination are common pathological features characterizing white matter and neurodegenerative disorders. Identifying the signaling pathways involved in myelin repair through oligodendroglial progenitor matu...
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Transferrin (Tf) has a major role in T cell activation and proliferation. Here, we investigated whether Tf exerts immunomodulatory effects on T cells and in development of T-cell driven experimental autoimmune encephalomyelitis (EAE). Wh...
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Oligodendrocytes are the cells producing the myelin membrane around the axons in the central nervous system and, although apotransferrin (aTf) is required for oligodendrocyte differentiation, the underlying mechanisms are not fully under...
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New clinical trial
Assessing the Validity and Reliability of the Language Memory Test for Use in a Belgian Population of People With Multiple Sclerosis

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Tolerogenic dendritic cell (tolDC) vaccines are a promising antigen-specific therapy for multiple sclerosis (MS), yet their efficacy is limited by poor homing to secondary lymphoid organs and rapid loss of the tolerogenic phenotype in na...
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Clemastine fumarate, a first-generation H1 antihistamine, has emerged as a promising candidate for drug repurposing in neurodegenerative and neuropsychiatric disorders owing to its ability to cross the blood-brain barrier and interact wi...
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Eur J Pharmacol. 2026 Oct 6:179393. doi: 10.1016/j.ejphar.2026.179393. Online ahead of print. ABSTRACT Tetanus toxoid (TT), a widely administered prophylactic immunogen, not only provides protection against tetanus but also exerts neurom...
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