📢 New Article in #LiversMDPI

🧬 Chamarthi et al. compared AFP, PIVKA-II, and the ASAP score for HCC diagnosis in 1305 participants.

🩺 ASAP showed the best overall diagnostic performance across multiple HCC subgroups.

📖 Read More: www.mdpi.com/2673-4389/6/...

#HCC #AFP #PIVKAII #MASLD

📢 New Review in #LiversMDPI

🧬 Colella et al. review gut microbiota changes in NAFLD/MASLD.

🩺 No consistent microbial signature was reproduced across populations, disease stages, and platforms.

📖 Read More: www.mdpi.com/2673-4389/6/...

#NAFLD #MASLD #GutMicrobiota #fibrosis

📢 New Review in #LiversMDPI

🧬 Stem et al. examine fructose–alcohol interactions in MetALD.

🩺 Pathways include mitochondrial dysfunction, lipid metabolism, and gut–liver axis disruption.

📖 Read More: www.mdpi.com/2673-4389/6/...

#MetALD #Fructose #Hepatotoxicity

📢 New Article in #LiversMDPI

🧬 Delnicki et al.: Females were more vulnerable to Cr(VI) exposure in liver and blood.

🩺 Males were more vulnerable to essential metal changes in the brain.

📖 Read More: www.mdpi.com/2673-4389/6/...

#Chromium #Liver #Blood #Brain

📢 New Article in #LiversMDPI

🧬 Aregawi et al. identified 6 HBV genotypes among 778 patients in a Canadian cohort.

🩺 Genotype C had the highest HBeAg positivity prevalence at 23.7%.

📖 Read More: www.mdpi.com/2673-4389/6/...

#HBV #HBVGenotype #HBeAg

📢 New Review in #LiversMDPI

🧬 Ichimura-Shimizu et al. propose a mechanism-oriented framework for MASH model selection.

🩺 Covers iHFC diet and TSOD/TSNO mouse models in a complementary landscape.

📖 Read More: www.mdpi.com/2673-4389/6/...

#MASH #AnimalModels #Fibrosis #BileAcids

📢 New Article in #LiversMDPI

🧬 Paolini et al. found a 9.7% biliary leakage incidence among 370 patients.

🩺 Operative time >5 h was the sole independent predictor of overall leakage.

📖 Read More: www.mdpi.com/2673-4389/6/...

#Hepatectomy #RiskFactors

📢 New Review in #LiversMDPI

🧬 Lonardo et al. review liver fibrosis assessment, management, and prevention.

🩺 Fibrosis can regress when the injurious stimulus is controlled, notably at F0–F2.

📖 Read More: www.mdpi.com/2673-4389/6/...

#LiverFibrosis #Cirrhosis

📢 New Review in #LiversMDPI

🧬 Gasparro et al. review 2D, animal, and advanced 3D models used to investigate hepatic IRI.

🩺 They discuss the strengths and limitations of each approach.

📖 Read More: www.mdpi.com/2673-4389/6/...

#HepaticIRI #3DModels

📢 New Review in #LiversMDPI

🧬 Vemula et al. review second- and third-line strategies after ICI failure in HCC.

🩺 TKIs remain the most widely used second-line option, while evidence for ICI rechallenge remains limited.

📖 Read More: www.mdpi.com/2673-4389/6/...

#HCC #TKIs

📢 New Case Report in #LiversMDPI

🧬 Cook et al. present a 60-year-old man diagnosed with ASM after bone marrow and liver biopsies confirmed mast cell infiltration
🩺 The patient developed noncirrhotic portal hypertension

📖 Read More: www.mdpi.com/2673-4389/6/...

#Mastocytosis #LiverDisease

📢 New Article in #LiversMDPI

🧬 Panconesi et al.: 4 grafts met previously reported FMN thresholds during HOPE.

🩺 Low FMN release showed greater ATP recovery and reduced inflammatory signaling.

📖 Read More: www.mdpi.com/2673-4389/6/...

#HypothermicOxygenatedPerfusion #FMN #ATP

📢 New Review in #LiversMDPI

🧬 Tabata examines whether GGA diversion toward 2,3-diGGA may influence hepatic tumor surveillance.

🩺 The review evaluates the GGA/2,3-diGGA ratio as a candidate biomarker.

📖 Read More: www.mdpi.com/2673-4389/6/...

#GGA #HCC

📢 New Review in #LiversMDPI

🧬 Digital and biological twins in cholangiocarcinoma

🩺 Fully realized medical digital twins remain unavailable, while biological twins face scalability and standardization challenges.

📖 Read More: www.mdpi.com/2673-4389/6/...

#PrecisionOncology #Cholangiocarcinoma

📢 New Article in #LiversMDPI

🧬 TJLB was technically successful in 86 of 100 cases.
🩺 A larger HV–IVC confluence angle was associated with technical failure; the 56° cutoff remains exploratory.

📖 Read More: www.mdpi.com/2673-4389/6/...

#LiverBiopsy

📢 New Article in #LiversMDPI

🧬 In Japanese patients with HCV, interferon-free DAA therapy was associated with early HRQoL improvements.
🩺 Generic utility scores changed little.

📖 Read More: www.mdpi.com/2673-4389/6/...

#HepatitisC #DAAs #HRQoL

📢 New Review in #LiversMDPI

🧬 Kaur et al. review PPAR agonists across PBC and other liver diseases.

🩺 The review covers molecular pharmacology and clinical and preclinical evidence.

📖 Read More: www.mdpi.com/2673-4389/6/...

#PPARAgonist #PBC #MASLD #Fibrosis

📢 New Article in #LiversMDPI

🧬 Cardoso et al. compared oral and IP acetaminophen administration in mouse models of ALF.

🩺 Effective doses: 500 mg/kg oral; 400 mg/kg IP.

📖 Read More: www.mdpi.com/2673-4389/6/...

#Acetaminophen #AcuteLiverFailure #PreclinicalModels

📢 Editor’s Choice in #LiversMDPI

🧪 Pyka et al. developed FibroScan® cap geometries for non-invasive liver assessment using a pig model.
🧬 In vivo results showed high agreement with the numerical model.

📖 More: brnw.ch/21x5qSt

#Elastography #PigLiver #FibroScan

📢 Call for Reading in #LiversMDPI

🔬 Villanueva Raisman et al. quantified 108 proteins in 2 µL of plasma.
🧬 Potential biomarkers for stratifying liver fibrosis were identified.

📖 Read More: brnw.ch/21x5oWo

#Fibrosis #Proteomics #MassSpectrometry