@epigenometech.bsky.socialEpigenetics Update - Histone lactylation scarring transmits metabolic and epigenetic memory across the gut-liver axis www.cell.com/cell-metabol...
#Epigenetics #Chromatin #Lactylation #EpigeneticMemory #Metabolism #GutLiverAxis
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High-resolution insights without cell sorting; epigenometech.com
@sigtrans-sttt.bsky.socialResearchers reveal how glycerol-derived lactate drives H4K5 histone #Lactylation and a FOXP3–GK feedback loop in regulatory T cells, enhancing #Immunosuppression in #ColorectalCancer liver metastases.
@genesndiseases.bsky.socialCould lactate-driven epigenetic changes shape cardiac recovery after #MyocardialInfarction?
This review explores histone lysine #lactylation and its interactions with other #PTMs in ischemia/reperfusion injury, revealing new targets.
#GenesAndDiseases: doi.org/10.1016/j.ge...
@mapjournals.bsky.social#EPI
Histone lactylation links lactate metabolism to epigenetic reprogramming of immune cells, driving inflammation, macrophage polarization, and tumor immune evasion.
Details: https://www.maxapress.com/article/doi/10.48130/epi-0026-0008
#HistoneLactylation #Immunoregulation #Lactylation
@sigtrans-sttt.bsky.socialProtein #Lactylation connects cellular metabolism with #Epigenetic regulation.
This review examines its molecular machinery and functions across physiology and disease, highlighting #Biomarker and therapeutic potential.
@ptmbio.bsky.socialA recent study published in Circulation (IF=41.3) revealed a new mechanism by which lactylation regulates myocardial ischemia/reperfusion injury.
Read the paper:https://doi.org/10.1161/circulationaha.126.081410
#Lactylation #Proteomics #PTM #CardiovascularResearch #Epigenetics