@rupress.orgIn @jgp.org, Hariharan, Longden et al. @medschool.umaryland.edu show that in a mouse model of #Alzheimers disease, capillary blood flow control fails early: endothelial Kir2.1 currents decline at 2–4 mo, followed by pericyte KATP channel impairment by 6–8 mo. rupress.org/jgp/article/...
#IonChannels
@jgp.orgHariharan, Longden et al. @medschool.umaryland.edu show that in a mouse model of #Alzheimers disease, capillary blood flow control fails early: endothelial Kir2.1 currents decline at 2–4 mo, followed by pericyte KATP channel impairment by 6–8 mo. rupress.org/jgp/article/...
@iamshanovao.bsky.social🚀 Worldwide Sodium Channel Seminars are back for Season 4!
Starts Nov 3 with talk from Samantha Salvage on cardiac Nav: "Targeting the cardiac sodium channel and its alternatively spliced variants with fragment antibodies"
Program & link to connect: lnkd.in/e7TRu8Hn
@gmj-georgia.bsky.socialMagnesium sits inside your NMDA receptor channel like a cork in a bottle, preventing neurons from firing randomly. When magnesium runs low, this safety gate… #Ionchannels #Magnesium #Neurologicalhealth #Neuroscience #NMDAreceptor #Ionchannels #Magnesium #Neurologicalhealth #Neuroscience #NMDAre…
@jgp.org📣 Call for Papers ⏰ DEADLINE NOVEMBER 30, 2026 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26. Submit here 👉 rupress.org/jgp/pages/ca...
@plesslab.bsky.socialGrateful for funding by @DFF @novo-nordisk.bsky.social @lundbeckfonden.bsky.social
#ProteinDesign #DeNovoDesign #IonChannels #Stroke #CryoEM #Electrophysiology #DrugDiscovery
@auditorynerves.bsky.social
@pflugers-archiv.bsky.social👁️ Light-sensitive cells can also respond to acidity. A recent study highlights functional acid-sensing ion channels in cultured primate rods and cones, adding to our understanding of retinal cell physiology.
@plesslab.bsky.socialVery excited about every single one of the five abstracts that my group has been involved in that were submitted for the BPS 2027 meeting in Philly!
@jgp.org📣 Call for Papers ⏰ DEADLINE EXTENDED: November 30 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca...
@jgp.orgState-dependent inhibition of LRRC8 volume-regulated anion channels by DCPIB. New study from Toshiki Yamada, Erkan Karakas, and Jerod S. Denton @vanderbilt.edu:
rupress.org/jgp/article/...
@jgp.orgA fluorescent non-hydrolyzable probe for the nucleotide binding sites of KATP. New study from Priscilla Rubio, Michael C. Puljung and coleagues @trinitycollege.bsky.social:
rupress.org/jgp/article/...
#Biochemistry #Biophysics #MolecularPhysiology #CellularPhysiology #IonChannels
@jgp.orgYamada, Karakas, & Denton @vanderbilt.edu show that the prototypical LRRC8/VRAC inhibitor DCPIB stabilizes an inactivated channel state through coordinated interactions spanning extracellular, transmembrane, & N-terminal channel domains rupress.org/jgp/article/...
#IonChannels #MolecularPharmacology
@francejeunes.bsky.socialVulnérabilité aux canicules : ce que nos gènes expliquent vraiment ❓ Les gènes rendent-ils certains plus vulnérables aux canicules ? ❓ Qu'est-ce qu'une protéine de choc thermique ? ❓ Le gène TRPV1 protège-t-il des canicules ? #genetics #heatwave #ionchannels
@jgp.orgThe proximal N terminus of IRAG is required for potentiation of HCN4 channels. New study from Lucas M. Blecker, John R. Bankston and colleagues @cuanschutz.bsky.social:
rupress.org/jgp/article/...
#MolecularPhysiology #MembraneTransport #Biophysics #IonChannels
@jgp.org📣 Call for Papers ⏰ DEADLINE EXTENDED TO NOVEMBER 30, 2026 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26. Submit here 👉 rupress.org/jgp/pages/ca...
@rupress.orgHeart rate is controlled, in part, by the opening and closing of the ion channel HCN4. In @jgp.org, Blecker, Bankston and colleagues describe the functionally relevant domains of both the channel and its ER-resident potentiator, IRAG. rupress.org/jgp/article/...
@jgp.orgHeart rate is controlled, in part, by the opening and closing of the ion channel HCN4. Blecker, Bankston and colleagues describe the functionally relevant domains of both the channel and its ER-resident potentiator, IRAG. rupress.org/jgp/article/...
@pstemkowskiphd.bsky.socialThose that know, know 'Resurgence' was no coincidence ⚡🧠
#scienceinart #ionchannels #neuroscience
@jgp.orgThe many faces of #Orai1 dysfunction: Molecular mechanisms and clinical manifestations. New review from Magdalena Prantl, Lara Atzgerstorfer, Isabella Derler and colleagues @jku.at:
rupress.org/jgp/article/...
#IonChannels #Biophysics #ProteinDynamics #MembraneTransport #Pathophysiology
