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@americanaging.bsky.socialOct 11, 2026, 8:13 PM

Immune aging may hit males earlier 🧬 In mice, naive CD8+ T cells decline sooner, lymph nodes shrink, and tumor recognition drops. Thymus regeneration helped. Mouse data, preprint.
doi.org/10.1101/2025...
#Immunosenescence

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@aging-us.bsky.socialOct 6, 2026, 12:00 AM

🧬 BehindtheStudy:
Dr. Falak Pahwa, Dr. Ranjan Kumar Nanda, and Mr. Ashish Gupta @icgebofficial.bsky.social, discuss “Host immunosenescence compromises Mycobacterium tuberculosis clearance.”

🎥 https://bit.ly/4h6ApmN

#Aging #Interview #Authors #Tuberculosis #Immunosenescence #Publishing #Research

@mapjournals.bsky.socialOct 4, 2026, 10:30 AM

#Targetome
Immunosenescence destabilizes the bone marrow immune niche in osteoporosis; natural products may reprogram microenvironmental targets.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0040
#Osteoporosis #Immunosenescence #BoneMarrow #NaturalProducts

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@alicefrolov.bsky.socialSep 28, 2026, 5:31 PM

Weakening of the DC–T Cell Immunological Synapse with Age

I am sharing a data visualization from ongoing conceptual work on age-associated remodeling.

#Immunosenescence #DendriticCells #ImmunologicalSynapse #TCellActivation #Costimulation #LigandReceptorInteractions

Weakening of the DC–T Cell Immunological Synapse with Age I am sharing a data visualization from ongoing conceptual work on age-associated remodeling of dendritic cell–T cell communication at the immunological synapse. The figure, "Weakening of the DC–T Cell Immunological Synapse with Age," is rendered as a curved bipartite flow map (ligand-receptor arc diagram), with dendritic cell ligands on the left axis and cognate T cell receptors on the right. Arc width and opacity encode simulated signaling strength, contrasted between young and aged tissue states. I want to be explicit that the underlying values are simulated. They are not drawn from a single empirical dataset but are parameterized to reproduce trends consistently reported in the immunosenescence literature. The visualization is intended as a mechanistic scaffold for discussion rather than as primary evidence. The mapped interactions include the peptide-MHC Class II to TCR-CD3 axis, the costimulatory CD80/CD86 to CD28 pair, CD40 to CD40L feedback, ICAM-1 to LFA-1 adhesion, and inhibitory PD-L1 to PD-1 signaling. In the aged condition, the diagram depicts attenuated pMHCII–TCR and CD80/86–CD28 arc weights, consistent with reduced antigen presentation efficiency and diminished costimulatory competence in aged DCs. Concurrently, the PD-L1–PD-1 arc is broadened, reflecting the shift toward inhibitory tone described in exhausted and senescent T cell compartments. ICAM-1–LFA-1 attenuation is included to represent reported deficits in synapse stability and conjugate formation. The composite effect illustrated here is a quantitative and qualitative degradation of productive synaptic signaling, favoring incomplete T cell priming and skewed activation thresholds. I would welcome critique on the ligand-receptor pair selection and on plausible weighting priors that could later be constrained with single-cell interactome or spatial proteomic data.
@sigtrans-sttt.bsky.socialSep 27, 2026, 3:15 AM

Researchers show that targeting BIRC6 disrupts a Treg-driven pathway that supports aged HSC survival, helping rebalance #hematopoiesis, reduce #Immunosenescence, and improve immune function in models of #Aging.

#STTT #OpenAccess: doi.org/10.1038/s413...
#Hematology #Immunology

Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence