Great talk by Douglas Mitchell at #ICBS2026.
He gave exciting insights into ribosomally synthesized and post-translationally modified peptides (RiPPs) that fold into lasso peptides and their potential to treat cancer.
@stephanhacker2.bsky.social
@stephanhacker2.bsky.socialGreat talk by Douglas Mitchell at #ICBS2026.
He gave exciting insights into ribosomally synthesized and post-translationally modified peptides (RiPPs) that fold into lasso peptides and their potential to treat cancer.
@stephanhacker2.bsky.socialInteresting talk by Ziyang Zhang at #ICBS2026.
He presented his group's exciting work on small molecules that enhance GTP hydrolysis by KRAS with important implications in switching off signaling by KRAS Q61 mutants in cancer cell lines.
@stephanhacker2.bsky.socialInspiring ICBS Global Lectureship Award lecture by Peng Chen at #ICBS2026.
He gave exciting insights into the power of genetic code expansion to better understand PTMs and to enable new chemistry in living cells.
@stephanhacker2.bsky.socialCongratulations to Yilong Zou on being one of the 2026 ICBS Young Chemical Biologist Awardees #ICBS2026.
He gave a great award lecture: "Chemical basis and intervention of ferroptosis in cancer and tissue injury"
@stephanhacker2.bsky.socialInteresting talk by Elena Reckzeh at #ICBS2026.
She gave a broad overview of the many different applications of organoids in Drug Discovery that her group is developing.
#Organoids #DrugDiscovery #ChemBio #ChemSky #DrugDevelopment
@stephanhacker2.bsky.socialThank you to the International Chemical Biology Society for inviting me to present some of our latest research today in San Francisco.
#ICBS2026 is truly an amazing conference. Thank you to Michelle Arkin and her team for the great organization.
Photo credit: @billy-ng.bsky.social
@stephanhacker2.bsky.socialO-GlcNAcylation is a posttranslational modification with important implications in health and disease.
In his talk at #ICBS2026, @billy-ng.bsky.social gave an overview, how they use proximity-inducing OGTACs to introduce this modification on target proteins.
@stephanhacker2.bsky.socialAmazing talk by Brian Paegel at #ICBS2026.
He talked about his group's exciting work on using DNA-encoded libraries for phenotypic screening for effectors of human signaling and for #antibiotics.
@stephanhacker2.bsky.socialGreat talk by Jason Gestwicki at #ICBS2026.
He talked about the many different structures that Tau fibrils can adopt and how this relates to different neurodegenerative disorders. He also gave great insights into their dynamics.
pubs.acs.org/jacsat/artic...
#Neuroscience #ChemBio #ChemSky #Science
@stephanhacker2.bsky.socialGreat talk by Chimno Nnadi at #ICBS2026.
"Deep Learning Guided Phenotypic Drug Screen Uncovers Structure-Activity-Relationships of Pyrazoloquinolinones"
@stephanhacker2.bsky.socialExciting talk by Evan Miller at #ICBS2026.
He talked about his group's work on novel NIR fluorophores based on bis(trifluoromethyl)carborhodamine and their application for live cell microscopy and activity-based sensing.
@stephanhacker2.bsky.socialCan the properties of psychedelics be optimized into safe, non-cardiotoxic and non-hallucinogenic antipsychotic drugs?
Great talk by David Olson (@deolsonlab.bsky.social) at #ICBS2026 on their work in this field in the context of lysergic acid diethylamide analogs.
@stephanhacker2.bsky.socialInteresting talk by Jie Liu from thr group of Kevan Shokat at #ICBS2026.
He talked about the development of BisRoc, a bivalent rocaglamide, that functions as a molecular glue to form higher-order eIF4A-RNA complexes for cancer cell-specific translation suppression
@stephanhacker2.bsky.social
@stephanhacker2.bsky.socialHow can we specifically address RNA with small molecules?
Amanda Garner gave an exciting talk at #ICBS2026, in which she discussed her group's work on developing tools for studying small molecule-RNA interactions in cells and disrupting RNA-protein interactions.
@stephanhacker2.bsky.socialGianluca Sbardella opened the third day of #ICBS2026 and introduced the EFMC - European Federation for Medicinal Chemistry and Chemical Biology and the EFMC Young Scientists Network.
@stephanhacker2.bsky.socialInsightful keynote lecture by Tanja Kortemme at #ICBS2026.
She took us on a tour through modern de novo #ProteinDesign from the design of "simple" #protein binders to dynamic proteins and complex reaction #networks in cells.
@stephanhacker2.bsky.socialInteresting talk by Ross Sibley from the group of Alison Axtman at #ICBS2026.
He talked about his work on casein kinase 2 (CK2)-directed PROTACs for targeting #Alzheimers.
@stephanhacker2.bsky.socialWhat to do, if cancer cells become resistant to a #CovalentInhibitor by mutating the reactive cysteine?
At #ICBS2026, Celine Wang from the group of Ziyang Zhang talked about her research into addressing BTK C481S with a β-lactone that targets the catalytic lysine.
@stephanhacker2.bsky.socialHow can we target pathogenic bacteria by attacking their communication systems?
Isabel Cannell from the group of Helen Blackwell gave exciting insights at #ICBS2026 into modulating bacterial #QuorumSensing with small molecules.
