What changed? #L1 affected the expression of genes/proteins in pathways linked to #HallmarksOfAging, including:
🧬 cell cycle & DNA damage (with flow validation)
⚙️ proteostasis
🧱 extracellular matrix
📡 immune signaling
🍽️ nutrient-sensing
3/7

New cell research: SIRT1 protects the genome by blocking "jumping genes" (LINE-1) from copying themselves elsewhere — a mechanistic clue behind a decade of sirtuin longevity research. Cell-based only so far, not yet in animals/people.
lifespan.io/a-mechanisti...

#GeroScience #HallmarksOfAging