Epigenetics Update - Histone lactylation scarring transmits metabolic and epigenetic memory across the gut-liver axis www.cell.com/cell-metabol...

#Epigenetics #Chromatin #Lactylation #EpigeneticMemory #Metabolism #GutLiverAxis
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High-resolution insights without cell sorting; epigenometech.com

Ulcerative colitis remission leaves persistent LCN2+ macrophages with heightened glycolysis and H3K9la memory.

#MASLD #GutLiverAxis #LiverSky #Hepatology
https://doi.org/10.1016/j.cmet.2026.09.008

🦠 New in eGastroenterology

🧬Intestinal neutral ceramidase fuels MASH by reshaping microbiota and increasing 2-HHA, which suppresses AhR–FUT2 fucosylation.

🧱 #MASH #MASLD #Microbiome #GutLiverAxis

🔗https://doi.org/10.1136/egastro-2026-100417
🔗https://doi.org/10.1136/egastro-2026-100458