Distinct mechanical regulation of PFK1 isoforms during cytoskeletal remodeling. New study from Logan W. Dawson, Kris A. DeMali and colleagues (University of Iowa Carver College of Medicine):
rupress.org/jcb/article/...
@jcb.org
@jcb.orgDistinct mechanical regulation of PFK1 isoforms during cytoskeletal remodeling. New study from Logan W. Dawson, Kris A. DeMali and colleagues (University of Iowa Carver College of Medicine):
rupress.org/jcb/article/...
@sigtrans-sttt.bsky.socialENO1 connects #Glycolysis with #GastricCancer stemness by regulating ATP pools and lactate homeostasis, which coordinate AMPK/mTOR and PI3K/AKT signaling to promote EMT, self-renewal, migration, and invasion.
@sigtrans-sttt.bsky.socialTKTL1-driven #Glycolysis increases lactate and promotes #Immunosuppressive dendritic-cell signaling in #HCC. Targeting the TKTL1–HIF-1α–HK2 axis and lactate reprograms the #TumorMicroenvironment to enhance PD-1 blockade.
