🔥 Brilliants minds debate oral fosfomycin for complicated UTI including pyelonephritis. With increasing ESBLs, we need options for UTI beyond cystitis. Oral fosfomycin is an appealing option, but is it ok for infection outside the bladder?

🔥 Brilliants minds debate oral fosfomycin for complicated UTI including pyelonephritis. With increasing ESBLs, we need options for UTI beyond cystitis. Oral fosfomycin is an appealing option, but is it ok for infection outside the bladder?
Oral #fosfomycin is non-inferior to continued IV therapy after 3–7 days of IV antibiotics for complicated UTIs caused by ESBL-producing #Enterobacterales.
A potential carbapenem-sparing step-down strategy in selected patients who have already improved.