A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, significantly enhancing prevention trial efficacy and addressing high NNT issues. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals CDK11's role in spliceosome activation and DHX15's proofreading. Discoveries made through SF3B1 phosphorylation insights and inhibitor OTS964 effects. PMID:42399621, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75109-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleoproteomic analysis of dental enamel from 23 H. naledi specimens (20 individuals) reveals no male markers, hinting at a possible single-sex sample. Exciting findings! PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals the structure of the moving junction in Plasmodium falciparum: a 1:1:1:1 assembly of PfAMA1 & PfRON2, 4, 5. Key for invasion! PMID:42379167, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00699-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionizing treatments: a deep learning method uses de novo protein WRAPs to solubilize membrane proteins, enhancing analysis! PMID:42391386, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adr3817 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Systematic CRISPR screens in primary CD4+ T cells identified numerous pro- and anti-HIV factors, revealing diverse antiviral mechanisms and high-confidence hits. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Genetic variant rs17437411 reduces blood counts & protects from blood cancers. It disrupts a novel lncRNA between HOXA7 & HOXA9, highlighting its role in hematopoiesis. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals TMEM154/Galvanin as a key receptor that helps cells sense electrical fields, guiding migration towards the cathode. Exciting insight into cell behavior! PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore 78 cell types in the macaque AIC, uncovering connectivity, signal-processing, and metabolic strategies of von Economo neurons. PMID:42393360, Nat Cell Biol 2026, @NatureCellBio https://doi.org/10.1038/s41556-026-02009-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights on cellular senescence reveal 7 distinct "senotypes" in aging tissues, unlocking pathways for 10+ novel biomarkers and targeted senotherapeutics. PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Neural timescales span vast ranges within/across brain areas, reflecting dynamic info processing. Mechanisms and roles still under study! Curious? 🧠✨ PMID:42393348, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02343-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Unveiling wing magic: Single-cell RNA sequencing in Pyrrhocoris and Nilaparvata reveals 6 cell types. Silencing 51 marker genes shows genes like En in morph development! PMID:42393067, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75225-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mechanical cues regulate liver regeneration via PIEZO1 in mid-lobular hepatocytes, key due to DPP4. A precise zonation of growth! PMID:42391361, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aef0825 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how Cdc48 powers proteolysis for organellar proteins from ER, mitochondria, and chloroplasts, overcoming membrane barriers for UPS degradation in cells. PMID:42393036, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74728-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

NIH's stricter genomic data security rules are slowing research. Experts call for oversight, but compliance remains a challenge. PMID:42391380, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aek1828 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A genome-scale map reveals ~89,000 genetic interactions in HAP1 cells, organizing ~4 million gene pairs into modules, enhancing understanding of gene co-essentiality! PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revamping rice with reprogrammed DELLA turnover improves yield & nitrogen-use efficiency. Boosts sustainability, retaining benefits of 1960s Green Revolution varieties! 🌾 PMID:42393083, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75068-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Macrophages lacking INSIG1 worsen psoriasis via SREBP2-STAT1, with human lesions showing INSIG1 inversely linked to IL-23, IL-17A. Deeper insights into skin autoimmunity. PMID:42393041, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73278-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A library of ~12,000 viral ORFs from 513 species was developed to uncover viral regulators of cell growth, MHC class I, and interferon signaling. Key insights await! PMID:42392077, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00583-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI advances CAR T cell therapy by discovering GPNMB targets, enhancing efficacy in multi-cancer treatment via integrated single-cell RNA sequencing from 1,000+ datasets. PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪