@primrlab.bsky.social(6)
#CysticFibrosis #PrecisionMedicine #Kalydeco #FibroseCística
#MedicinaDePrecisão #Ivacaftor #PrIMR
The U.S. Food and Drug Administration's Experience with Ivacaftor in Cystic Fibrosis. Establishing Efficacy Using In Vitro Data in Lieu of a Clinical Trial
DOI: doi.org/10.1513/anna...
@uoft-tcairem.bsky.social🩻 #Artificialintelligence improves #chest #Xray interpretation employing magnetic resonance imaging (#MRI) as ground truth in #patients with #cysticfibrosis |
@cysticfibrosis.org.ukThis year, we agreed to fund early career researcher Dr Jessica Lewis to advance her exciting preliminary results from lab-based studies investigating new phage treatments for BCC.
#ResearchWednesday #cysticfibrosis #cftrust #phagetherapy #AntimicrobialResistance
@primrlab.bsky.social(7) PT: A teratipagem e a teranóstica surgem como ferramentas poderosas para prever respostas individuais e ampliar o acesso ao tratamento. 👨🏻🔬🧬🔬🫁💊
#FibroseCística #MedicinaDePrecisão #ModuladoresDeCFTR
#CysticFibrosis #PrecisionMedicine #CFTRmodulators
#PrIMR
@primrlab.bsky.social@primrlab.bsky.social(2) EN: This binding helps stabilize NBD1 and the interdomain interactions of F508del-CFTR. Subsequent studies have shown their ability to restore function in other CFTR variants, along with their safety and effectiveness in clinical settings. 👨🏻🔬🧬🔬🫁💊
@primrlab.bsky.social(3) EN: Trials demonstrated modest but meaningful benefits when combined with the potentiator ivacaftor: ~3–4% improvement in lung function and ~30–35% reduction in exacerbations. 👨🏻🔬🧬🫁💊
#CysticFibrosis #PrecisionMedicine #Lumacaftor #Tezacaftor #PrIMR
@primrlab.bsky.social
@chazingdra.bsky.socialIt’s that time of year again! Today is my #cysticfibrosis annual review and I’ll be sharing updates as I go in this thread.
🔁 RTs for awareness appreciated 😊
CF is a genetic condition that causes a build-up of mucus affecting the whole body, especially the lungs.
@primrlab.bsky.social(2) EN: Medicinal chemistry efforts then improved their pharmacological properties, enabling these drugs to advance through clinical trials and deliver substantial benefits. Today, these drugs offer renewed hope to many eligible patients worldwide.
@cysticfibrosis.org.ukThe #cysticfibrosis EYIM is a unique opportunity to network with CF researchers across Europe, hear from mentors, share your work and make career-long new connections.
Apply by submitting an abstract by 11pm GMT on Sunday 25 October.
Click the link to find out more.
@primrlab.bsky.social(3) EN: Looking ahead, advances in multi-omics, AI, and functional testing could help make precision care a routine part of treatment. 👨🏻🔬🧬🔬🫁💊
#PrecisionMedicine #RespiratoryDiseases #PersonalizedTherapy #Asthma #COPD #CysticFibrosis #PulmonaryFibrosis #PrIMR
@lifearc.bsky.socialWhy choose a career in cystic fibrosis research?
4 researchers from across the CF Lung Health Network share what inspires them in their work every day.
@gmj-georgia.bsky.socialNew research shows CFTR modulators reduce anxiety in children with cystic fibrosis AND their parents. Better l… #Anxietymentalhealth #CFTRmodulators #Chronicdiseasemanagement #Cysticfibrosis #Paediatricrespiratorydisease #Anxietymentalhealth #CFTRmodulators #Chronicdiseasemanagement #Cysticfibr…
@healthcare-europe.bsky.socialTo fight #cysticfibrosis at the source, scientists have both identified a key #infection mechanism and a way to correct the defect. Their insights could help limit serious complications in #CF patients.
@soumya-goblue.bsky.socialactually very similar to what @ranaawdish.bsky.social described 2 days ago. a close friend with #cysticfibrosis died of #renalfailure, which she found out is a horrible way to die. But we learned in #medicalschool that #uremia is a good way to die…because patients are quiet to doctors and nurses
@cysticfibrosis.org.ukOver the past two years, the Translational Innovation Hub Network for CF Lung Health and Infection has brought together researchers, clinicians, people with #cysticfibrosis and partners across the UK and beyond to make real progress against CF lung infections.
➡️ www.cysticfibrosis.org.uk/network
@primrlab.bsky.social(2) EN: 3) ~70% of CF alleles carry a three-base deletion (F508del), with the remaining cases caused by many rarer variants. Together, these findings launched molecular diagnosis and research in CF.
@newsuluruspace.bsky.socialByły Wallaby z Cystic Fibrosis zdiagnozowany z MND
https://news.uluru.space/article/26370?utm_source=bluesky&utm_medium=social&utm_campaign=auto #Rugby #Choroby #Mnd #CysticFibrosis
@chrisvandergast.bsky.socialGreat to see this finally out
Impact of #trikafta/#kaftrio on respiratory microbiomes of adults with #cysticfibrosis from UK,US,& Canada
Also shows negative selective impacts of azithromycin on #CF pathogens & #microbiome
A need to reevaluate CF polypharmacy in the #CFTR modulator era?