Integrated transcriptome + nasal microbiota profiling in 132 #CRSwNP patients revealed 4 endotypes with distinct immune-microbial signatures and steroid responses. Staphylococcus-dominated Cluster C had the highest add-on systemic corticosteroid response.
#Immunology #Microbiome
🔗 ino.to/SOmXkNW

In #CRSwNP, nasal fibroblasts sense TLR3 signals and, via TRIF/p38/JNK/PI3K-AKT, release IL-6, CXCL8, CCL2, and CCL11-driving eosinophil recruitment and linking innate immune activation to eosinophilic inflammation and remodeling.
#Rhinology #Immunology

🔗 onlinelibrary.wiley.com/doi/10.1002/...

In AERD, 8 weeks of high-dose aspirin (ATAD) left most mediators unchanged but increased nasal IL-27, decreased IL-5/CCL11, and showed responder vs nonresponder differences in CXCL13, IL-25, and CCL13, exploratory signals that need larger studies.
#N-ERD #CRSwNP #Rhinology
🔗 ino.to/KWqY7oN