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Version devBuilt at: 2026-10-19 04:14:37 EDT

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@sigtrans-sttt.bsky.socialOct 17, 2026, 2:00 AM

Can targeting lipid metabolism improve treatment of SDH-deficient gastrointestinal stromal tumors? This phase 1b study reports promising activity of olverembatinib, which suppresses CD36 expression and lipid uptake.

#STTT #OpenAccess: doi.org/10.1038/s413...
#CancerMetabolism #LipidUptake

Olverembatinib, a multikinase inhibitor that modulates lipid metabolism, in advanced succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 1b study and translational research
@herranzlab.bsky.socialOct 5, 2026, 5:54 PM

📢Interested in #CancerMetabolism and #leukemia using mouse models in vivo? Come join us!! We're looking for a #postdoc to help us drive one of our multiple currently funded projects! Friends & colleagues, please RT!
👇👇👇
jobs.rutgers.edu/postings/276...

@sigtrans-sttt.bsky.socialSep 17, 2026, 6:02 AM

ME1 is a direct L-lactate sensor that connects #Lactate signaling with HDGF-associated EMT and ME1–LDHB-mediated metabolic adaptation, shaping tumor plasticity across heterogeneous metabolic conditions.

#STTT #OpenAccess: doi.org/10.1038/s413...

#CancerMetabolism #LactateSignaling

Malic enzyme 1 senses L-lactate to determine tumor heterogeneity
@ptmbio.bsky.socialSep 16, 2026, 8:11 AM

A Weill Cornell Medicine study reveals that BCAA-derived propionyl-CoA promotes SREBP2 propionylation, stabilizing SREBP2 and enhancing cholesterol and androgen production.

PTM BIO antibody cited: PTM-201

read the paper: doi.org/10.1038/s422...

#Propionylation #PTM #CancerMetabolism

@alicefrolov.bsky.socialSep 14, 2026, 5:03 PM

Sharing a visualization from our ongoing modeling work on intratumoral oxygen dynamics and the HIF-1α-driven transcriptional response.

#TumorHypoxia #HIF1alpha #TumorMicroenvironment #Angiogenesis #OxygenSensing #VEGF #ComputationalOncology #CancerMetabolism

Sharing a visualization from our ongoing modeling work on intratumoral oxygen dynamics and the HIF-1α-driven transcriptional response. Figure: "Oxygen tension collapse drives coordinated hypoxia-angiogenesis program across the tumor radius" Subtitle: "Simulated intratumoral pO₂ gradient from vessel wall to necrotic core with HIF-target activation" The figure uses a horizon-style stacked area representation (layered oxygen-gradient contour strip) to render pO₂ as a function of radial distance from the perfused vessel wall toward the necrotic core. Each contour band encodes a discrete oxygen tension interval, with marker overlays indicating the activation thresholds of canonical HIF-1α target loci. I want to emphasize that the underlying data are simulated; the parameterization reflects diffusion-limited oxygen distributions consistent with published Krogh-cylinder estimates and the well-characterized ~100–200 µm diffusion limit. The central observation is the coordinated character of the transcriptional program along the radial axis. Proximal to the vessel wall, pO₂ remains above the threshold for prolyl hydroxylase domain (PHD/EGLN) activity, sustaining VHL-mediated HIF-1α degradation. As oxygen tension declines toward the intermediate perinecrotic zone, PHD activity becomes substrate-limited, HIF-1α escapes hydroxylation and proteasomal turnover, and it accumulates to drive HRE-dependent transcription. The marker overlays illustrate the staggered engagement of glycolytic effectors (SLC2A1, LDHA), pH-regulatory targets (CA9), and pro-angiogenic signaling (VEGFA) as the gradient steepens. The horizon-strip format was chosen deliberately to compress the steep radial pO₂ decay into a legible vertical encoding while preserving the coincidence between tension thresholds and target activation.
@cnag-eu.bsky.socialSep 3, 2026, 10:15 AM

2⃣ 𝗧𝗵𝗲 𝗼𝗯𝗷𝗲𝗰𝘁𝗶𝘃𝗲
... what if we could also map how cells use energy and nutrients within a tumour?

🔐 This information has remained inaccessible until now, but it could be key to understanding the metabolic strategies that support tumour growth

#CancerResearch #CancerMetabolism