💡New paper! Predicted off-targets for Seladelpar and Zanamivir with AlphaFold3 + MD, then tested the top 3. All inactive. For PPARγ, 4 of 5 AF3 models put the drug ~8 Å off - the only correct pose scored lowest confidence. Stability ≠ function.
link.springer.com/article/10.1...
#alphafold #boltz2