KI researchers have mapped how atypical #BCells develop and change function over time. In @embojournal.org, they show that these cells arise from different precursors but converge on a shared late differentiation stage, helping clarify their roles in #Immunity 🧪 news.ki.se/immune-cells...

📢 New in Discovery Immunology

New open-access research shows a strikingly shared (“public”) antibody response following PRV vaccination and challenge, revealed through porcine BCR repertoire profiling 🧬

🔗 vist.ly/5mz8c

#Immunology #Vaccines #Bcells #OpenAccess

These immune-cell changes were most evident in #Bcells in which EBV often lies dormant and were linked to antiviral responses and inflammation.Studies were able to detect these changes in blood samples up to 3 months before people with MS experienced a relapse.

www.sciencealert.com/up-to-3-mont...

🧪 The order of immune signals matters. A human B-cell model reproduces germinal-centre features in culture, including somatic hypermutation. A useful research tool—not a complete germinal centre.
doi.org/10.1126/scii...
#Immunology #BCells

For those of us without a convenient supply of human tonsils, here's another way to generate human GC B cells in culture: #science #immunology #Bcells www.science.org/doi/10.1126/...

ER #proteostasis failure in HYOU1 deficiency alters #Bcells, #neutrophils, and #interferon signaling. New study from Aida Idani, Raphael Carapito, Seiamak Bahram @seiamak.bsky.social @unistra.fr and colleagues:
rupress.org/jhi/article/...

#InbornErrorsOfImmunity

Better #CancerImmunotherapy requires tackling hidden immune barriers.
This review highlights how dysfunctional #Bcells suppress anti-tumor immunity and outlines strategies to reprogram the #TumorMicroenvironment.
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...

In @jem.org, Michalets et al. demonstrate that upper respiratory tract tissue-resident memory #CD8⁺ T cells are sufficient to protect against respiratory virus transmission, even in the absence of #CD4 #Tcells, #Bcells, or lower respiratory tract immune responses. rupress.org/jem/article/...

Michalets, Kohlmeier et al. demonstrate that upper respiratory tract tissue-resident memory #CD8⁺ T cells are sufficient to protect against respiratory virus transmission, even in the absence of #CD4 #Tcells, #Bcells, or lower respiratory tract immune responses. rupress.org/jem/article/...

#WIMMReads 🧪

A new review from the Bannard Group explores how #BCells are selected in germinal centers and how diverse, lasting antibody immunity develops.

https://onlinelibrary.wiley.com/doi/10.1111/imr.70169 

#Immunology #MRCWIMM @medsci.ox.ac.uk @ndm.ox.ac.uk