explore | Grilled Cheese

@medchemexpress.bsky.social Oct 12, 2026, 10:30 PM

📰A new study in Cell identifies #GIMAP6 as a key protective factor against atherosclerotic cardiovascular disease (#ASCVD), revealing a mechanism beyond conventional lipid-related risk.
https://www.cell.com/cell/fulltext/S0092-8674(26)01134-7

@thelancetendo.bsky.social Oct 11, 2026, 9:25 AM

#Familial #hypercholesterolaemia is an autosomal, semi-dominant condition characterised by markedly elevated plasma #LDL #cholesterol concentration from birth, xanthomas, & early onset of #atherosclerotic #cardiovascular disease (#ASCVD) thelancet.com/journals/lan...
#HeFH #HoFH

#EndoSky #CardioSky

Previous manifestations of ASCVD, especially myocardial infarction and an elevated coronary plaque burden on cardiac CT, indicate a higher risk for ASCVD events. The risk depends not only on very high LDL cholesterol concentrations or exposure to elevated LDL cholesterol during lifetime, but also on the presence or risk biomarkers like male sex, high lipoprotein(a), low HDL cholesterol, high BMI and blood pressure, family history of early ASCVD, smoking and comorbidities like diabetes and chronic kidney disease. Specific familial hypercholesterolaemia risk equations, such as SAFEHEART-RE and the familial hypercholesterolaemia risk score, can integrate this risk. ASCVD risk might also be modulated by the effect of genes unrelated to lipids, as aggregated in a polygenic risk score. LDL cholesterol should always be reduced in patients with familial hypercholesterolaemia. Severe familial hypercholesterolaemia is a clear indication for more intensive LDL cholesterol lowering with PCSK9 inhibitors. ASCVD=atherosclerotic cardiovascular disease.

@vindicomeded.bsky.social Oct 1, 2026, 7:45 PM

Are you involved in the management of patients with or at risk of #ASCVD? This activity is for you: https://www.healio.com/cme/lipidcme/assessing-cvd-risk/20260806/lipid-management-in-an-era-of-evolving-evidence?utm_source=Bluesky&utm_medium=post&utm_campaign=H704

@rcatanho.bsky.social Oct 1, 2026, 5:33 AM

En adultos c/diabetes tipo 2 y sobrepeso/obesidad, IL-6 identifica riesgo de insuficiencia cardíaca en adultos sin antecedentes de enf CV, intervención intensiva en el estilo de vida dirigida a perder peso reduce la IL-6 en un año #HF #ASCVD #CVD #IL6 www.jacc.org/doi/10.1016/...

@thelancetendo.bsky.social Sep 29, 2026, 9:45 AM

Also read the original TimeCapsule article:
A quarter-century of progress: innovations in lipid medicine that transformed cardiovascular prevention thelancet.com/journals/lan...
#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.social Sep 29, 2026, 9:45 AM

25 Years of Lipid Medicine youtube.com/watch?v=atCH...
#LDL #cholesterol #ASCVD
#statins #PCSK9 inhibitors

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.social Sep 23, 2026, 8:35 AM

#Cholesterol-lowering medicine has changed almost beyond recognition over the past 25 years — from early #statin trials to today's longer-acting, less frequently dosed therapies, some of which may eventually require only one or two doses a year www.youtube.com/watch?v=atCH...
#LDL #ASCVD

#EndoSky

@accintouch.bsky.social Sep 21, 2026, 7:27 PM

🆕 New in #CardiologyMag:
🔹 Antiplatelet therapy guidance for #ASCVD
🔹 DOAC guidance for preventing thrombotic events
🔹 Updated global HF definition to improve #cvPrev, diagnosis & treatment

Read the latest clinical guidance 👉 https://bit.ly/3V4ldOw

#JACC #CardioSky #ClinicalGuidelines

@thelancetendo.bsky.social Sep 20, 2026, 3:12 PM

Also check out the Video Abstract:
25 Years of Lipid Medicine youtube.com/watch?v=atCH...
#LDL #cholesterol #ASCVD

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.social Sep 19, 2026, 12:42 PM

This TimeCapsule reviews the major transformations in #lipid #metabolism & #cardiovascular #disease #prevention during the first quarter of the 21st century & their impact on clinical practice thelancet.com/journals/lan...
#LDL #cholesterol #ASCVD
#FREE to read w/reg (also FREE)

#EndoSky #cardioSky

@thelancetendo.bsky.social Sep 17, 2026, 7:46 PM

25 Years of #Lipid Medicine
youtube.com/watch?v=atCH...

#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors #ezetimibe #RNA-based drugs #gene editing

@thelancetendo.bsky.social Sep 14, 2026, 11:23 AM

Despite advances, #familial #hypercholesterolaemia is still inadequately diagnosed and undertreated, with many affected people remaining at high risk of early #cardiovascular #disease www.thelancet.com/journals/lan...
#HeFH #HoFH #ASCVD #LDL #cholesterol

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.social Sep 14, 2026, 10:16 AM

This TimeCapsule reviews the major transformations in #lipid #metabolism and #cardiovascular #disease #prevention during the first quarter of the 21st century and their impact on clinical practice www.thelancet.com/journals/lan...
#LDL #cholesterol #ASCVD
#FREE to read w/reg (also FREE)

#EndoSky

The upper and lower blue bands represent the principal concepts that have driven clinical practice. Along both sides of the timeline arrow are the acronyms of the main randomised controlled trials. Positive outcome trials are shown in black and negative ones in red. Grey squares indicate studies that led to changes in guidelines and conceptual frameworks. Negative trials that influenced guideline development are shown in orange. Non-trial studies are in italic font. At the base of the timeline arrow are studies that laid the foundation at the end of the 20th century. The upper right section highlights emerging developments, including new molecular targets and innovative lipid-lowering therapies. See the appendix (pp 1–6) for details on the studies.
ANGPTL3=angiopoietin-like 3. PCSK9=proprotein convertase subtilisin/kexin type 9.

@thelancetendo.bsky.social Sep 10, 2026, 3:26 PM

Video Abstract—25 Years of Lipid Medicine youtube.com/watch?v=atCH...
#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors
#ezetimibe #RNA-based drugs #gene editing

#MedSky #EndoSky #CardioSky

@thelancetendo.bsky.social Sep 8, 2026, 8:09 PM

Also read the original TimeCapsule article:
A quarter-century of progress: innovations in lipid medicine that transformed cardiovascular prevention www.thelancet.com/journals/lan...
#LDL #cholesterol #ASCVD
#FREE to read with registration (also FREE)

#MedSky #EndoSky

@thelancetendo.bsky.social Sep 8, 2026, 8:09 PM

New Video Abstract:

25 Years of Lipid Medicine www.youtube.com/watch?v=atCH...
#LDL #cholesterol #ASCVD #statins #PCSK9 inhibitors

#MedSky #EndoSky