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@schilvi.bsky.socialOct 15, 2026, 6:45 PM

Let’s do this: #injection number #fortysix with #Ajovy, an #antibody for migraine prophylaxis 💉. Number twenty-eight after the break.

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@antibodytx.bsky.socialOct 14, 2026, 1:54 PM

Antibody Therapeutics (IF=4.8, Oxford University Press) ⚡ Review Highlight -Fundamental properties and principal areas of focus in antibody–drug conjugates formulation development.
doi.org/10.1093/abt/...
#mab #antibody #antibodies #adcs #formulation #formulationdevelopment

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@biotium.bsky.socialOct 13, 2026, 9:19 PM

Bring Autumn's Bright Colors to Your Research! 🍂🔬

"Fall" in love with our #fluorescent stains and dyes in warm autumnal hues. biotium.com/technology/c...

#reagents #labhelp #sciencecompany #nuclearstaining #antibody #dnaresearch #cadaverine #scienceart #naturescience

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@cellseq.bsky.socialOct 13, 2026, 7:04 PM

Antibody is an essential tool in molecular biology research, enabling the detection and analysis of specific proteins. The Elabscience ELK1 Polyclonal Antibody (E-AB-90026) is designed for researchers investigating ELK1.
For more info visit: cellseq.in/blog/antibod...

#antibody #elk1antibody #elk1

@mdpipharma.bsky.socialOct 12, 2026, 10:49 AM

🎯 NK cells engineered via #lipid-based #antibody capture—no #gene #modification! AC-NKs bind trastuzumab, T-DM1 & sacituzumab, enhancing cytotoxicity against #HER2+ & Trop-2+ #tumors. Scalable & programmable!

📌 www.mdpi.com/1999-4923/17...
#Immunotherapy #NKcells #CancerResearch

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@zoonoses-journal.orgOct 12, 2026, 10:03 AM

KM299-L05 induced broad neutralizing antibodies and complete maternal #antibody-mediated protection in mice, supporting its potential as a future CVB5 vaccine candidate. #medsky #Virology
#Zoonoses #OpenAccess: doi.org/10.15212/ZOO...

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@abhishekgarglab.bsky.socialOct 10, 2026, 6:05 PM

🌅 #Research #Alert
Large-scale #GWAS meta-analysis of #serum #antibody levels in #healthy individuals reveals distinct #genetic #architectures

👉 Access here: www.nature.com/articles/s41...
@springernature.com #Genes & #Immunity

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@plosbiology.orgOct 9, 2026, 12:05 PM

Researchers often select antibodies based on previous use or peer recommendations. This study shows that poor #antibody validation contributes to substantial avoidable consumption of animal and human biological samples, proposing interventions to improve #reliability.
🧪 #AcademicSky
plos.io/4s1Ccxl

Self-reported antibody validation practices among researchers. Distribution of IWGAV pillar usage among survey respondents (n = 107). Of 107 respondents, 77 (72.0%) used at least one IWGAV-aligned validation strategy, while 30 (28.0%) used no IWGAV pillars, relying instead on technical controls only (n = 26) or performing no validation (n = 4). Among IWGAV users, 44 used a single pillar, 22 used two pillars, 10 used three pillars, and 1 used five pillars.
@plosbiology.orgOct 8, 2026, 8:05 AM

Researchers often select antibodies based on previous use or peer recommendations. This study shows that poor #antibody validation contributes to substantial avoidable consumption of animal and human biological samples, proposing interventions to improve #reliability.
🧪 #AcademicSky
plos.io/4s1Ccxl

Self-reported antibody validation practices among researchers. Distribution of IWGAV pillar usage among survey respondents (n = 107). Of 107 respondents, 77 (72.0%) used at least one IWGAV-aligned validation strategy, while 30 (28.0%) used no IWGAV pillars, relying instead on technical controls only (n = 26) or performing no validation (n = 4). Among IWGAV users, 44 used a single pillar, 22 used two pillars, 10 used three pillars, and 1 used five pillars.
@hellobio.bsky.socialOct 7, 2026, 10:27 AM

Choosing the right antibody can make a big difference to the reliability of your results, and in this new article we share 6 key things to look for in antibody validation evidence 🙌

Read here: https://ow.ly/Eszq50ZVige

#antibody #antibodies #reproducibility #lifescience #validation #lifescience

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@aqlm.bsky.socialOct 6, 2026, 12:12 AM

Tip 2: Maximize your likelihood for useful information.
Do the #experiment to determine #antibody concentration or exposure time.

Tip 3: The endeavor of #science is *figuring out how* to answer the question.
Failure can't be completely avoided, though see Tip 1 to avoid total chaos.

@plosbiology.orgOct 5, 2026, 4:15 PM

Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design.
🧪 #AcademicSky #virus
plos.io/4rNWkD5

V1WT_06 binds to the RBD site V epitope using the heavy chain alone. A) A closeup view of the superimposed structure of V1WT_06 bound to WIV-1 RBD on a trimeric spike (from PDB: 8WLZ). A clash with NTD of chain B is observed when V1WT_06 Fab-RBD complex is aligned onto RBD in the up conformation (chain A) in trimeric WIV-1 spike protein. Notably, the binding site is inaccessible in the RBD-down conformation. B) V1WT_06 heavy chain only interaction with WIV-1 RBD (grey). Heavy and light chains are shown with the dark and light blue ribbons, respectively. C) V1WT_06 epitope footprint overlayed with epitope footprints of other site V neutralising antibodies including S2H97, CC25.4, 5817, R1-32, and E465 patch. SARS-CoV-2 RBD (from PDB: 6m0j) is coloured based on the amino acid conservation across 87 bat sarbecoviruses.
@plosbiology.orgOct 5, 2026, 4:10 PM

How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns.
🧪 #AcademicSky
plos.io/4y9KgxG

Cryo-EM structure of RhGB07 trimeric spike in a 3-RBD down state. (A) Left: CryoEM density of the trimer spike coloured by the protomer chains the density originates from. Glycans are highlighted in teal. Centre: the trimeric spike viewed from the top rendered in cartoon representation. Right: the isolated RhGB07 RBD represented as cartoon in grey with two glycans of interest shown. (B) The C-alpha trace of the RBD of RhGB07 rendered as balls-and-sticks superimposed with the RBD of SARS-CoV-1 (PDB 7DF3) and SARS-CoV-2 (PDB 5X5B). The insets show a zoomed-in view of two regions of the RBD that show the greatest changes in the position of the C-alpha of the RBD. The region containing the ins1-loop and delta4-loop coincides with putative ACE2-interacting residues based on mapping the equivalent residues of SARS-CoV-1 and SARS-CoV-2. The ACE2-interacting residues were determined by superimposing SARS-CoV-1 and RhGB07 RBD onto the SARS-CoV-2 RBD – ACE2 (PDB: 6M0J) structure and identifying interacting residues. Highlighted residues of RhGB07 show the putative interacting residues that differ in identity to SARS-CoV-2.
@pharmaphorum.bsky.socialOct 5, 2026, 9:16 AM

#CSL has licensed rights to a potentially first-in-class #anticlaudin1 #antibody developed by #AlentisTherapeutics in a #deal that could be worth up to $1.55 billion.

pharmaphorum.com/news/csl-joi...

@plosbiology.orgOct 4, 2026, 12:15 PM

Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design.
🧪 #AcademicSky #virus
plos.io/4rNWkD5

V1WT_06 binds to the RBD site V epitope using the heavy chain alone. A) A closeup view of the superimposed structure of V1WT_06 bound to WIV-1 RBD on a trimeric spike (from PDB: 8WLZ). A clash with NTD of chain B is observed when V1WT_06 Fab-RBD complex is aligned onto RBD in the up conformation (chain A) in trimeric WIV-1 spike protein. Notably, the binding site is inaccessible in the RBD-down conformation. B) V1WT_06 heavy chain only interaction with WIV-1 RBD (grey). Heavy and light chains are shown with the dark and light blue ribbons, respectively. C) V1WT_06 epitope footprint overlayed with epitope footprints of other site V neutralising antibodies including S2H97, CC25.4, 5817, R1-32, and E465 patch. SARS-CoV-2 RBD (from PDB: 6m0j) is coloured based on the amino acid conservation across 87 bat sarbecoviruses.
@plosbiology.orgOct 4, 2026, 12:10 PM

How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns.
🧪 #AcademicSky
plos.io/4y9KgxG

Cryo-EM structure of RhGB07 trimeric spike in a 3-RBD down state. (A) Left: CryoEM density of the trimer spike coloured by the protomer chains the density originates from. Glycans are highlighted in teal. Centre: the trimeric spike viewed from the top rendered in cartoon representation. Right: the isolated RhGB07 RBD represented as cartoon in grey with two glycans of interest shown. (B) The C-alpha trace of the RBD of RhGB07 rendered as balls-and-sticks superimposed with the RBD of SARS-CoV-1 (PDB 7DF3) and SARS-CoV-2 (PDB 5X5B). The insets show a zoomed-in view of two regions of the RBD that show the greatest changes in the position of the C-alpha of the RBD. The region containing the ins1-loop and delta4-loop coincides with putative ACE2-interacting residues based on mapping the equivalent residues of SARS-CoV-1 and SARS-CoV-2. The ACE2-interacting residues were determined by superimposing SARS-CoV-1 and RhGB07 RBD onto the SARS-CoV-2 RBD – ACE2 (PDB: 6M0J) structure and identifying interacting residues. Highlighted residues of RhGB07 show the putative interacting residues that differ in identity to SARS-CoV-2.
@plosbiology.orgOct 3, 2026, 8:15 AM

Sarbecovirus spillover presents an urgent need for cross-reactive antibodies with therapeutic potential. This study uncovers the mechanisms of broad sarbecovirus cross-reactivity of three human antibodies that can inform the rational #antibody design.
🧪 #AcademicSky #virus
plos.io/4rNWkD5

V1WT_06 binds to the RBD site V epitope using the heavy chain alone. A) A closeup view of the superimposed structure of V1WT_06 bound to WIV-1 RBD on a trimeric spike (from PDB: 8WLZ). A clash with NTD of chain B is observed when V1WT_06 Fab-RBD complex is aligned onto RBD in the up conformation (chain A) in trimeric WIV-1 spike protein. Notably, the binding site is inaccessible in the RBD-down conformation. B) V1WT_06 heavy chain only interaction with WIV-1 RBD (grey). Heavy and light chains are shown with the dark and light blue ribbons, respectively. C) V1WT_06 epitope footprint overlayed with epitope footprints of other site V neutralising antibodies including S2H97, CC25.4, 5817, R1-32, and E465 patch. SARS-CoV-2 RBD (from PDB: 6m0j) is coloured based on the amino acid conservation across 87 bat sarbecoviruses.
@plosbiology.orgOct 3, 2026, 8:10 AM

How ACE2 receptor usage shapes sarbecovirus host range and antigenicity remains unclear. This study screens bat sarbecoviruses, identifying those #viruses with generalist and specialist tropism and characterizing their #antibody neutralization patterns.
🧪 #AcademicSky
plos.io/4y9KgxG

Cryo-EM structure of RhGB07 trimeric spike in a 3-RBD down state. (A) Left: CryoEM density of the trimer spike coloured by the protomer chains the density originates from. Glycans are highlighted in teal. Centre: the trimeric spike viewed from the top rendered in cartoon representation. Right: the isolated RhGB07 RBD represented as cartoon in grey with two glycans of interest shown. (B) The C-alpha trace of the RBD of RhGB07 rendered as balls-and-sticks superimposed with the RBD of SARS-CoV-1 (PDB 7DF3) and SARS-CoV-2 (PDB 5X5B). The insets show a zoomed-in view of two regions of the RBD that show the greatest changes in the position of the C-alpha of the RBD. The region containing the ins1-loop and delta4-loop coincides with putative ACE2-interacting residues based on mapping the equivalent residues of SARS-CoV-1 and SARS-CoV-2. The ACE2-interacting residues were determined by superimposing SARS-CoV-1 and RhGB07 RBD onto the SARS-CoV-2 RBD – ACE2 (PDB: 6M0J) structure and identifying interacting residues. Highlighted residues of RhGB07 show the putative interacting residues that differ in identity to SARS-CoV-2.
@antibodytx.bsky.socialSep 30, 2026, 3:05 PM

Antibody Therapeutics (IF=4.8, Oxford University Press) ⚡ Review Highlight -CAR NK cell therapy for solid tumors: potential and challenges
doi.org/10.1093/abt/...
#mab #mabs #antibody #antibodies #antibodydiscovery #antibodytherapeutics #biologics #naturalkillercells #CAR #CARNK

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@gentlem.bsky.socialSep 26, 2026, 5:10 PM

knowablemagazine.org/content/arti...
#autoimmune-encephalitis
#antibody-associated-psychosis
It is my experience & opinion that modern U.S. clinical psychiatry continues to do a disservice by being far too reluctant to medically rule out underlying conditions prior to aggressive tx w/antipsychotics.

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