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@plosbiology.orgOct 8, 2026, 4:15 PM

Why do some neurons die in #neurodegeneration while closely related neighbors survive? This Essay by Dong Won Kim argues that disease resistance may depend on maintenance of a neuron's #cell identity and proposes tests of the model.
🧪 #AcademicSky
plos.io/4y7cGbA

Reversible cell-state remodeling vs. identity-maintenance failure in adult neurons.
An adult neuron with stable subtype identity (left) depends on continued operation of four interrelated regulatory components, shown in the inset legend: (1) identity transcription factors; (2) accessible identity enhancers; (3) coherent terminal effector gene modules; and (4) active repression of alternative gene programs belonging to other cell types. Under stress (metabolic, proteostatic, inflammatory, or pathological), the neuron can follow one of two trajectories. (A) In reversible cell-state remodeling, the neuron mounts adaptive responses such as the heat-shock response and the unfolded protein response (UPR), while identity transcription factor activity, enhancer accessibility, terminal effector modules, and repression of alternative programs remain intact. When the stress is removed, the neuron returns to its prior identity state. (B) In identity-maintenance failure, similar stress responses occur, but the regulatory machinery that stabilizes subtype identity itself weakens: identity transcription factor activity falls, identity enhancers lose accessibility, terminal effector modules decohere, and repression of alternative or neighboring-cell programs (orange) fails, allowing those programs to be expressed. After sustained disruption of this machinery, return to the prior identity state may be incomplete, delayed, or unstable even after the initiating stress is removed (broken recovery arrow), and degeneration may follow. The stress-response components are shown at comparable intensity in both panels to emphasize that the framework concerns identity-regulatory outcomes under matched stress exposure, not differences in stress response itself. Neuron illustration adapted from NIH BioArt Source, “Healthy neuron” (BIOART-000197), Public Domain, Courtesy of NIAID.
@prepub-neurodegen.bsky.socialOct 8, 2026, 4:02 PM

Mitigating Feature Entanglement and Imbalance in Driving Style Classification via Physically Isolated Hierarchical Transformers #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10734228/latest

@prepub-neurodegen.bsky.socialOct 8, 2026, 4:02 PM

A Novel Fuzzy Hybrid Deep Learning Architecture for Spatiotemporal PM2.5 Prediction #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11058151/latest

@prepub-neurodegen.bsky.socialOct 8, 2026, 4:02 PM

Bioaccumulation of polychlorinated biphenyls (PCBs) in Pseudotolithus senegalensis from the coastal waters of Apam and Shama, Ghana: implications for human health risk #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-11151832/latest

@prepub-neurodegen.bsky.socialOct 8, 2026, 4:02 PM

A Novel HANDLE-Based NGS Assay for Fast and Comprehensive HRR Alteration Profiling in Prostate Cancer #NeuroDegeneration 🧪🧠
https://www.researchsquare.com/article/rs-10671913/latest

@papers-neurodegen.bsky.socialOct 8, 2026, 1:03 PM

Alzheimer’s disease target and drug discovery by leveraging multiomics and electronic health data #NeuroDegeneration 🧪🧠
https://www.nature.com/articles/s41593-026-02472-0

@papers-neurodegen.bsky.socialOct 8, 2026, 1:03 PM

Sleep-dependent microglial functions in Alzheimer’s disease #NeuroDegeneration 🧪🧠
https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(26)00187-6?rss=yes

@prepub-neurodegen.bsky.socialOct 8, 2026, 1:02 PM

Cross-Tissue Inflammatory Convergence Supports a Putative Muscle-Brain Axis in Alzheimer's Disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.10.07.751107v1

@prepub-neurodegen.bsky.socialOct 8, 2026, 1:02 PM

Intracranial electrophysiology reveals distinct neural representations of nociception and salience in the human brain #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755799v1

@prepub-neurodegen.bsky.socialOct 8, 2026, 1:02 PM

The effects of temporal smoothing and interpolation on EEG microstate parameters, syntax, and our view of resting-state brain dynamics #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755764v1

@prepub-neurodegen.bsky.socialOct 8, 2026, 1:02 PM

msengine: Adaptive Open-Source Signal Extraction for HDX MS #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755802v1

@prepub-neurodegen.bsky.socialOct 8, 2026, 1:02 PM

Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755839v1

@prepub-neurodegen.bsky.socialOct 8, 2026, 1:01 PM

Targeting microglial P2Y12-receptor signalling attenuates neurodegeneration in experimental Parkinsons disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.10.02.756181v1

@prepub-neurodegen.bsky.socialOct 8, 2026, 1:01 PM

Ethmoid bone marrow region modulates lymphoid activation and differentiation with distinct myeloid profile in neuroinflammation #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.10.03.755016v1

@prepub-neurodegen.bsky.socialOct 8, 2026, 1:01 PM

Sex-dependent DNA methylation in amyotrophic lateral sclerosis #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.09.30.755680v1

@prepub-neurodegen.bsky.socialOct 8, 2026, 1:01 PM

Pharmacological Effects and Candidate Bioactive Constituents of Huanglian Wendan Decoction in Experimental Metabolic Syndrome: Multi-Omics Analysis of Gut-Liver Metabolism and NLRP3 Signaling #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.10.05.756920v1

@papers-neurodegen.bsky.socialOct 8, 2026, 10:05 AM

Longitudinal clinical outcomes after amyloid clearance in aducanumab phase 3 studies #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71758?af=R

@papers-neurodegen.bsky.socialOct 8, 2026, 10:05 AM

miR‐214‐3p and NCKAP1: A microglial functional dimension of Alzheimer's progression #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71903?af=R

@papers-neurodegen.bsky.socialOct 8, 2026, 10:05 AM

Genetic evidence supports a cortical neuroprotective role of GLP‐1 receptor activation in Alzheimer's disease: A drug‐target Mendelian randomization study #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71845?af=R

@papers-neurodegen.bsky.socialOct 8, 2026, 10:05 AM

The value of timely treatment with anti‐amyloid therapy for Alzheimer's disease #NeuroDegeneration 🧪🧠
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71819?af=R

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