@abangelabs.bsky.socialGermany opens a migraine-acupuncture consultation around a three-trial evidence base. https://www.mattheneus.com/editorial/g-ba-acupuncture-migraine-prevention-consultation-three-trial-evidence-2026-09-24 #HTA #EvidenceSynthesis #RegulatoryAffairs
@abangelabs.bsky.socialSixty-eight percent of occupational heat studies stayed in the lab, leaving a field-effectiveness evidence gap. https://www.mattheneus.com/editorial/occupational-heat-stress-laboratory-field-effectiveness-evidence-gap-2026-09-26 #HTA #EvidenceSynthesis #RWE
@abangelabs.bsky.socialAn NMA ranks clozapine, paliperidone and olanzapine highest for reducing aggression in schizophrenia. Evidence certainty remains low. #HTA #NMA #EvidenceSynthesis https://www.mattheneus.com/editorial/pubmed-antipsychotic-aggression-network-meta-analysis-low-certainty-2026-09-24
@abangelabs.bsky.socialBCI robotic rehabilitation ranks first for post-stroke arm recovery, with clinical relevance still uncertain. #HTA #EvidenceSynthesis https://www.mattheneus.com/editorial/pubmed-stroke-bci-robot-rehabilitation-network-clinical-threshold-2026-09-25
@abangelabs.bsky.socialAfrica’s childhood vaccine evidence base contained just one budget-impact analysis, exposing a critical gap for decision-makers. https://www.mattheneus.com/editorial/africa-childhood-vaccine-economic-evidence-budget-impact-gap-2026-09-24 #HTA #HealthEconomics #EvidenceSynthesis
@abangelabs.bsky.socialHow often does living evidence stay living? Forty-one percent of syntheses issued an update within two years. #HTA #EvidenceSynthesis #Pharma https://www.mattheneus.com/editorial/living-evidence-synthesis-update-status-protocol-2026-09-25
@abangelabs.bsky.socialIQWiG sets a randomised-trial threshold for 3D intracardiac echocardiography, exposing the evidence gap.\nhttps://www.mattheneus.com/editorial/iqwig-h26-02-three-dimensional-intracardiac-echocardiography-randomised-evidence-gap-2026-09-23\n#HTA #EvidenceSynthesis
@abangelabs.bsky.socialSwedish survival projections rose when trial follow-up doubled, showing the sensitivity of HTA extrapolations. #HTA #HealthEconomics #EvidenceSynthesis https://www.mattheneus.com/editorial/pubmed-swedish-hta-oncology-survival-extrapolation-extended-follow-up-audit-2026-09-26
@abangelabs.bsky.socialWHO has set evidence thresholds for five contraceptive options, clarifying the path from emerging evidence to global guidance. #HTA #EvidenceSynthesis #RegulatoryAffairs https://www.mattheneus.com/editorial/who-expanding-contraceptive-options-five-evidence-thresholds-2026-09-23
@abangelabs.bsky.socialGlaucoma evidence has a publication gap: four in ten conference abstracts reached full publication within six years. #HTA #EvidenceSynthesis https://www.mattheneus.com/editorial/glaucoma-conference-abstract-full-publication-selective-dissemination-evidence-synthesis-2026-09-25
@abangelabs.bsky.socialHospital ward surveillance technologies still lack a clear effectiveness ranking in this Bayesian network meta-analysis. #HTA #NMA #EvidenceSynthesis https://www.mattheneus.com/editorial/pubmed-clinical-surveillance-technologies-non-icu-bayesian-network-meta-analysis-2026-09-24
@abangelabs.bsky.socialA costed menu for global evidence synthesis infrastructure puts 40 solutions at US$278.3 million. https://www.mattheneus.com/editorial/evidence-synthesis-infrastructure-costed-menu-data-duplication-investment-2026-09-21 #HTA #EvidenceSynthesis #HealthEconomics
@abangelabs.bsky.socialSix ways to record ethnicity, 21 ways to group it: subgroup comparisons stop meaning the same thing across studies. https://www.mattheneus.com/editorial/race-ethnicity-ascertainment-categorisation-clinical-research-subgroup-comparability-2026-09-21 #HTA #EvidenceSynthesis
@abangelabs.bsky.socialG-BA resumes three stem cell transplantation assessments in multiple myeloma. https://www.mattheneus.com/editorial/g-ba-stem-cell-transplantation-multiple-myeloma-assessment-resumption-2026-09-24 #HTA #EvidenceSynthesis #Pharma
@abangelabs.bsky.socialCapacity-based exclusions in trial protocols quietly narrow the population HTA bodies must later generalise to. https://www.mattheneus.com/editorial/clinical-trial-protocol-capacity-exclusions-population-relevance-2026-09-25 #HTA #EvidenceSynthesis #RegulatoryAffairs
@abangelabs.bsky.socialMost public health randomised trials report benefits and leave the harms column empty, which quietly distorts economic evaluation. #HTA #EvidenceSynthesis https://www.mattheneus.com/editorial/public-health-randomised-trials-harms-reporting-programme-economic-evaluation-2026-09-25
@abangelabs.bsky.socialZilucoplan in generalised myasthenia gravis: PubMed indexes MAIC results vs IVIg and two complement inhibitors.
#HTA #MAIC #EvidenceSynthesis
@cochrane.orgThis session of our GRADE Learning Live series will introduce the structured and practical GRADE approach for integrating (or not integrating) RCTs and NRSIs in evidence syntheses.
Join us to learn more!
📆 October 5, 10:00 - 11:30 UTC
🔗 www.cochrane.org/events/grade...
@abangelabs.bsky.socialIn under-fives, cost-utility models still lean on utility instruments validated in adults, and most studies never flag the substitution. https://www.mattheneus.com/editorial/paediatric-under-five-cost-utility-adult-utility-instruments-reporting-gap-2026-09-25 #HTA #HealthEconomics #EvidenceSynthesis
@trialschangelives.bsky.socialToday, searching PubMed for “COVID-19” limited to systematic reviews retrieves 12,000, a year since it reached 11,000. How many of these are needed? How much #ResearchWaste do they represent, 6 years on from this opinion piece?
blogs.bmj.com/bmj/2020/04/...