A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, enhancing prevention efforts beyond the CANTOS trial's NNT limitations. #CancerResearch PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A GWAS on 382 Hispanic newborns revealed 6 significant loci for 24 neonatal blood traits, highlighting chromosome 2p11.2's CD8A. #Genetics PMID:42385717, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S000292972600234X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Hippocampal theta sweeps show goal direction in navigation by evaluating potential future trajectories in under 121 cycles. Fascinating data! PMID:42386950, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02365-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights on SARS-CoV-2 relatives found in Thai horseshoe bats reveal 2 co-circulating clades; one binds human ACE2 tightly, raising pandemic concerns. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Replayed 100+ GC reactions to uncover B cell competition dynamics; deep mutational scanning revealed key affinity shifts, illuminating antibody evolution. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Phase 3 trial: adjuvant pembrolizumab + belzutifan tested on patients with clear-cell renal-cell carcinoma. Aim: better survival, less recurrence. PMID:42384869, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2518245 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how Complex I's intricate structure enables >300 Å proton-coupled electron transfer. A carboxylate switch point in the E-channel proves essential. Dive in! PMID:42386739, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74767-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals hippocampal neurons show shared semantic responses in bilinguals, highlighting "cross-language neurons" for concepts like "tierra" and "earth." Fascinating! PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 is crucial for safe and efficient reprogramming of human somatic cells to pluripotency, balancing genome stability while opposing oncogenic risks. #p53 PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity, identifying 100+ potential regulators influencing cell fate changes. Exciting times ahead! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Shining light on congenital myasthenia: correcting acetylcholine receptor mutations may improve muscle function and transform lives. Are breakthroughs near? PMID:42386970, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10706-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals Arc is essential for tau release via extracellular vesicles; rTg4510/Arc KO mice show reduced tau and seeding potential—key insights into neurodegeneration! PMID:42372723, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore how treatment thresholds in psychiatry are reshaped by clinimetric advances; key for optimized patient care in 2023. PMID:42384391, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1759 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

DNA hypomethylation in tomatoes aids SlSPL-CNR to bind and repress SlAAT1, altering f… PMID:42386734, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-75181-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study: 27 volunteers challenged with A/H3N2, 22 infected, 18 symptomatic. Rapid innate immune response linked to symptoms. PMID:42387215, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04483-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore the role of NUDT5 in 6-TG response; inhibition matters more than loss, boosti… PMID:42380098, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74489-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how the IDP ALMS1 influences centriole biogenesis! It catalyzes cartwheel formation by organizing CEP152 without becoming part of the structure itself. PMID:42380124, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74821-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New trimodal platform enables simultaneous in vivo Ca²⁺ imaging, neuron morphology reconstruction, and in situ transcriptomic profiling, advancing neuron function insights. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel in vivo screening platform was created using 84 CRISPR-Cas9 knockout mouse lines to validate host factors in influenza A research, bridging vital gaps in virology! PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A recent study on recurrent GBM highlighted that CAR T cell therapy showed early promise but nearly 50% relapse rates indicate a crucial role for immune response in outcomes. PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪