Grilled Cheese

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Grilled Cheese is a product of Village Compute

Version devBuilt at: 2026-10-16 08:00:47 EDT

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Clumps of orange jack-o-lantern mushrooms on the amid brown leaf litter.
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A low-angle, eye-level close-up photograph of a large bracket fungus growing at the base of a woodland tree. The fungus consists of overlapping, fan-shaped fronds with warm tan and chestnut-brown tops, wavy edges, and cream-coloured undersides. Fresh green grass and dark ivy leaves wrap around the base of the fungal rosette. The background is softly blurred with dappled sunlight glowing through soft green leaves and a quiet woodland path. The overall mood is earthy, peaceful, and autumnal.
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Conceptual diagram for the trade-off between biofilm production and in vivo persistence. Biofilm production facilitates colonization of commensal organisms, promotes adherence, and confers intrinsic antifungal resistance. Biofilm-producing strains are under tight transcriptional control and expose β-glucan. This leads to increased phagocytosis and killing by macrophages, and extracellular NET production by neutrophils. By contrast, Daneshnia and colleagues, show that low biofilm-producing strains undergo transcriptional reprogramming to allow for metabolic flexibility. They mask their β-glucan to facilitate immune avoidance, leading to decreased phagocytosis by macrophages. However, when phagocytosed, low biofilm-producing strains are more fit for growth and survival within immune cell-rich niches of the host, leading to enhanced macrophage activation and neutrophil swarming. Together these features allow low biofilm-producing C. parapsilosis strains to survive and persist within the in vivo host environment.
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Close up of a tree heather (erica arborea) tree in bloom (Adobe Stock)
Pretty Fly Fora Fungi - jolly wee Fly Agaric drinking fizz card
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Group of small white mushrooms with cream colored stems growing out of the scales of a pine cone
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