explore | Grilled Cheese

Study of 186 monoclonal antibodies from 28 aPAP patients reveals GM-CSF autoantibody affinity and epitope, not total titer, link to disease severity. Insights could advance treatments. PMID:42362542, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74717-2 #Medsky #Pharmsky #RNA 🧪

Real-time imaging of ErbB receptors using upconverting nanoparticles reveals that oncogenic EGFR mutations lead to stable, ligand-independent dimerization, shedding light on activation dynamics. PMID:42054992, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00399-5 #Medsky #RNA 🧪

A phytoscreen of 43 fruits and veggies reveals garlic as a strong deterrent of mating and egg-laying in Drosophila, with diallyl disulfide leading the way! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Primate organogenetic embryoids derived from cynomolgus totipotent blastomere-like stem cells (cTBLCs) demonstrate key totipotent features, paving the way for comprehensive embryogenesis studies. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky #RNA 🧪

LEAPER 3.0 enhances RNA editing by using designed ADAR-recruiting RNAs (arRNAs) for precise, efficient editing. Advances in AlphaFold 3 structure unlock new strategies! PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI-driven discovery identifies GPNMB as a promising CAR T cell target for multi-cancer therapy, optimizing tumor composition through single-cell RNA sequencing. #CancerResearch PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Discover how GCN5-related N-acetyltransferases creatively modify mature lasso peptides, introducing iterative acylation to enhance diversity! PMID:41826761, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02149-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

African populations hold 40% of human genetic diversity but are only 2% of genomic studies. Advocate for national genome projects to improve healthcare equity! PMID:42342701, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74952-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Estudo da Texas A&M revela que o acúmulo excessivo de RNA prejudica as mitocôndrias, comprometendo a geração de energia celular e ressaltando a importância da degradação do RNA para a saúde celular.

#rna #energia #mitocondrias #saudecelular #estudo

Heat stress increases metabolic dysfunction risk in mice when exposed to high-fat diets. Skin-derived KLK14 triggers hypothalamic LRRC7+ astrocytes, linking heat and metabolism. PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Osteosarcoma develops in juvenile metaphysis. Study shows p21 induction due to DNA damage in 3-5 immature osteoblast stages; 10-stage maturity path identified. PMID:42363015, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74929-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear envelope budding (NEB) permits the export of large RNA transcripts during myoblast differentiation into myotubes, revealing a vital role in cellular processes. PMID:42034051, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00386-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Gut bacteria metabolite imidazole propionate linked to Alzheimer's! In 1,196 adults, high plasma levels tied to lower cognitive scores & ADRD biomarkers. Fascinating discovery! PMID:42362546, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74744-z #Medsky #Pharmsky #RNA #ASHG 🧪

Complete response to pembrolizumab in dMMR prostate cancer with TMB >250 mutations/Mb and NK-like, CD4+CD8+ T cells! PMID:42361800, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S266637912600306X?rss=yes&utm_source=dlvr.it&utm_medium=twitter #Medsky #Pharmsky #RNA #ASHG 🧪

New study reveals that prion-based switches in S. cerevisiae enhance mutagenesis, enabling rapid adaptation in diverse environments. Key to evolution! PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative study tests 3KO porcine kidneys with 4 HTG combos. Results show promise: longer survival in primates, advancing xenotransplantation potential! 🌍👥 PMID:42362566, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74933-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals that CD8+ T cell antitumor immunity boosts tumor cell vulnerability to cuproptosis, enhancing the efficacy of cuproptosis inducers in immunocompetent settings. Immunogenic cell death… PMID:42330950, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00636-7 #RNA 🧪

Multiomic study reveals glutaminolysis enhances immune memory via lysine deacetylase inhibitors, boosting vaccine efficacy for high-risk groups like the elderly. PMID:42362565, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74866-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Systematic screens in primary human CD4+ T cells identified 50+ pro- and anti-HIV factors. CRISPRa revealed key antiviral mechanisms enhancing resistance to HIV. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪