TOMORROW: September Journal Club webinar!
Join this discussion on responsible biomedical data sharing—balancing discovery with ethical, legal, & social considerations. Register now to hear from Maya Sabatello and Ellen Wright Clayton: https://bit.ly/45nniah @ajhgnews.bsky.social #ASHG

A novel genetic system uncovers 4 distinct pathways for neuronal protein clearance in the brain, revealing 2 hotspots for drainage previously overlooked in standard tracer studies. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG 🧪

About 50% of fertilized eggs fail during human pre-implantation due to error-prone 2nd mitotic divisions. Stochastic centriole overduplication can be reduced by PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG 🧪

Exciting advances in RNA editing with LEAPER 3.0 utilize engineered ADAR-recruiting RNAs for precise editing, integrating AlphaFold 3 for improved efficiency. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exploring acetylcholine's diverse roles in the hippocampus from novelty to error correction. A new predictive lens emerges. 🌟 PMID:42337376, Nat Rev Neurosci 2026, @NatRevNeurosci https://doi.org/10.1038/s41583-026-01058-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A groundbreaking study maps 100+ senotype variations and interactions in human tissues via single-cell multi-omics, paving the way for 10+ targeted senotherapy strategies. PMID:42276030, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00587-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Rational discovery of direct small-molecule PAK1 activators unveils a novel autoinhibition-release site, enhancing therapeutic potential for cardiac health. Exciting advancements! PMID:41923641, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00275-8 #Medsky #Pharmsky #RNA #ASHG 🧪

Cisplatin's DNA damage in neurons activates nucleotide excision repair (NER), but instead of protecting, it leads to neuronal death, revealing a paradox in neurotoxicity. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Emerging insights reveal "disease-associated motor neurons" in ALS, marked by thousands of molecular changes in SOD1-G93A mice, redefining degeneration pathways. PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS, an AI platform, analyzes 18M+ cells from H&E histopathology to decode tumor microenvironment architecture, enhancing spatial tumor profiling and therapeutic insights. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore astrocytes via proteomics: proteins, not mRNA, drive diverse roles in neural circuits & disease, expanding insights! #AstroProteomics PMID:42337375, Nat Rev Neurosci 2026, @NatRevNeurosci https://doi.org/10.1038/s41583-026-01054-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how BoNT/E's flexible "belt" speeds up its action by swiftly translocating into neurons, compared to BoNT/A, promising faster treatments. PMID:42337249, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74499-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Neuron-specific translatomes in the hippocampus change rapidly during early memory consolidation. Elevated protein synthesis hints at unique neuronal functions. PMID:42336862, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74455-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP triggers membrane shearing via 3TM proteins to enhance phage immunity, revealing unique mechanisms behind cyclic-oligonucleotide defense strategies. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how MYDGF influences retinal neovascularization! Study reveals its role in retinal vessel growth via Gαi1/3-Gab1-Akt-mTOR. Breakthrough in vision research! PMID:42336863, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74780-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Whole-body spatiotranscriptomics in mice reveals 379 cell types from 59M single cells, enhancing understanding of histology and enabling advanced ML applications. PMID:41903540, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1, a key protein with a ZnF domain, to sense singlet oxygen (¹O₂) and activate photoprotection, revealing a conserved mechanism across species. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, linking gene regulatory networks to RNA velocity in 1 study, pinpointing candidates that may steer cell fates—transforming insights into 4D biology! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights from a study reveal Deep-Phase, a deep learning framework, measures drug-induced changes in biomolecular condensate morphology, linking structure to function. PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that macrometastases in breast cancer activate a Metastatic Trabecular Morphogenesis (MTM) program, repurposing developmental pathways for 3D expansion. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪