Revealing the seminiferous epithelial cycle using seqFISH+, a study profiled 2,653 genes in 867,062 mouse testis cells to show Sertoli cells sync their transcriptional patterns with spermatogenesis. PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #RNA 🧪

What's next for #lipid-based #RNA #delivery? This review covers rational vs combinatorial design, multiplexed formulation, #protein corona principles, biophysical mechanisms & #machine #learning approaches.

👉 doi.org/10.3390/phar...
#RNADelivery #LipidNanoparticles #Formulation #Nanomedicine

Visualizing #RNA dynamics in living plant cells at single transcript resolution is limited by high background fluorescence. This study develops a high signal-to-noise imaging platform that overcomes this barrier, revealing mRNA trafficking dynamics.
🧪 #AcademicSky #imaging #plants
plos.io/4ARoa5k

Malaria vaccine development struggles due to lack of T cell targets. Cross-stage, cross-species CD8⁺ T cell antigens identified for P. falciparum & P. vivax. PMID:42386975, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10730-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study discovers 7 de novo EHMT2 variants causing autosomal dominant Kleefstra syndrome. These reduce G9a methyltransferase activity, revealing new genetic insights. PMID:42386776, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74987-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

#RNA Framework 2.9.8 is out! Check the full CHANGELOG: github.com/dincarnato/R.... Get the latest version at: github.com/dincarnato/R...

This release features a major renovation of the engine. A few highlights in a short thread (1/n).

Study finds restoring cortical disinhibition reduces Huntington's symptoms. In-depth 2-photon imaging reveals roles of neuronal subtypes. HD movement disorder unravelled. PMID:42386967, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10671-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Developed a CRISPR knockout mouse library targeting 84 host genes for in vivo influenza A studies, paving the way for better understanding of viral pathogenesis. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits and veggies reveals garlic as a strong deterrent of mating and egg-laying in Drosophila. Diallyl disulfide, a garlic compound, inhibits both behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG 🧪

Prion-based switching of DNA repair proteins in Saccharomyces cerevisiae boosts mutagenesis rates, enabling rapid adaptation in diverse environments. Fascinating evolution insights! PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA 🧪

Targeted TFO liposome (tLipo-TFO1) reduces PAI-1, addressing pulmonary fibrosis by enhancing ECM clearance. PMID:42385711, Cell Rep Med 2026 https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(26)00326-5?rss=yes&utm_source=dlvr.it&utm_medium=twitter #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Metastasis in CRC is driven by tumor cell plasticity. TROP2, a marker linked to poor outcomes, associates with WNT^low and fetal-like states, fueling resistance. PMID:42386981, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10705-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

GLP-1 receptor agonists in hidradenitis suppurativa: study of mortality, CV events, and systemic complications in cohort. Discuss! 🔍 PMID:42384412, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.1907 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals change: 1 in 4 women, 1 in 100 men face military sexual trauma. Treatment up but suicidal thoughts persist. PMID:42160071, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1203 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Casdatifan, a potent HIF-2α inhibitor, shows durable antitumor activity in refractory metastatic ccRCC per ARC-20 study (NCT05536141). Manageable safety. PMID:42386974, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10718-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CANVAS leverages AI to decode tumor microenvironments from H&E histopathology, analyzing 18M+ cells to uncover spatial habitat dynamics influencing therapy response. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RegVelo integrates RNA velocity with gene regulatory networks to model single-cell dynamics more accurately. This innovative framework enhances understanding of cellular fate transitions by quantifying… PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #RNA 🧪

A genome-scale genetic interaction map in HAP1 cells reveals ~89,000 interactions, organizing genes into modules linked to protein complexes—key for targeted therapies! PMID:42049019, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00345-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering new enzymes with metal-coordination mining could transform enzyme prediction, linking genome insights to real-world applications. PMID:42386972, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10716-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Hippocampal theta cycles sweep spatial paths, aiding navigation by directing behavior to goals. Theta sweeps are task-relevant for rapid planning. #NeuralDynamics PMID:42386948, Nat Neurosci 2026, @NatureNeuro @Cornell https://doi.org/10.1038/s41593-026-02364-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪