Embryonic macrophages, emerging from yolk sac & fetal liver, shape tissue organization & immunity early on, becoming long-lived. PMID:42386903, Nat Rev Immunol 2026, @NatRevImmunol https://doi.org/10.1038/s41577-026-01327-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study bridges single-cell RNA seq with axonal projections in mouse visual cortex. A leap in linking diverse neurons—quantifies the brain at a new level. PMID:42386969, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10424-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal how VPS13A, a bridge-like lipid-transfer protein, collaborates with the scramblase XK via cryo-EM to mediate lipid transfer at organelle contact sites. PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study finds vessel fractional flow reserve (vFFR) from 3D coronary angiography rivals pressure-wire FFR in guiding heart interventions. Mitigates need for pressure wire and hyperemia across 37 sites! PMID:41910382, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2601841 #Medsky #Pharmsky 🧪

Nuclear and cytosolic proteomic profiling in human and murine neural stem cells reveals abundant cytoskeletal proteins like MAP1B that regulate fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1, a conserved ZnF domain protein, to sense singlet oxygen (¹O₂) and activate photoprotection, enhancing high-light tolerance in plants and animals. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A groundbreaking 3D DNase-Enhanced Expression Profiling (3DEEP) captures hundreds of hair follicles' dynamics in neonatal mouse skin, advancing understanding of organogenesis. PMID:42385701, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00702-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Do you know what a fever is? Here’s what you need to know about fevers from an ICU pharmacist in 60 seconds!

#MedSky #PharmSky #NurseSky

Cysteine's sulfur divides paths between glutathione & iron-sulfur clusters, crucially influencing CD8+ T cell proliferation, function, & anti-tumor immunity. Fascinating! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Polyploidy is a major evolutionary force in angiosperms, with 132 ancient WGD events analyzed across 470 species, revealing non-random clustering. Fascinating! PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Precision medicine's potential hinges on top-tier genome sequencing. Address key challenges: germline, tumor, cell-free DNA, genetic therapy standards. PMID:42387168, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10621-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Colorectal cancer liver metastases show striking heterogeneity: 5-year survival is <44.2% for 'replacement' vs. 73.4% for 'encapsulated.' No therapies yet. PMID:42386979, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10686-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting research: 34 circRNAs identified in blood for early Alzheimer's diagnosis. Predictive model matches plasma pTau217 effectiveness. PMID:42387213, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04485-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Malaria vaccine development struggles due to lack of T cell targets. Cross-stage, cross-species CD8⁺ T cell antigens identified for P. falciparum & P. vivax. PMID:42386975, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10730-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new study reveals that cell heterogeneity in intestinal regeneration is stabilized by chromatin at critical density regimes, integrating mechanochemical signals for robust patterning. 🍃🔬 PMID:42379166, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00696-3 #Medsky #Pharmsky 🧪

New study discovers 7 de novo EHMT2 variants causing autosomal dominant Kleefstra syndrome. These reduce G9a methyltransferase activity, revealing new genetic insights. PMID:42386776, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74987-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study finds restoring cortical disinhibition reduces Huntington's symptoms. In-depth 2-photon imaging reveals roles of neuronal subtypes. HD movement disorder unravelled. PMID:42386967, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10671-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Developed a CRISPR knockout mouse library targeting 84 host genes for in vivo influenza A studies, paving the way for better understanding of viral pathogenesis. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits and veggies reveals garlic as a strong deterrent of mating and egg-laying in Drosophila. Diallyl disulfide, a garlic compound, inhibits both behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG 🧪

Prion-based switching of DNA repair proteins in Saccharomyces cerevisiae boosts mutagenesis rates, enabling rapid adaptation in diverse environments. Fascinating evolution insights! PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA 🧪