Excessive mechanosensation via PIEZO1 in bladder epithelium leads to increased nociceptive innervation and chronic pain, linked to SLC7A11 and glutamate signaling. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Alphavirus M1, via NSP2, disrupts super-enhancer oncogenic transcription in osteosarcoma. Surprisingly, this isn’t just about ER stress or RPB1 involvement. PMID:42386745, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75013-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how plants respond to touch! A MAPKKK3/4/5-MKK4/5-MPK3/6 cascade is activated in 60s, inducing 800 genes—key for early mechanostimulation response. 🌿 PMID:42386747, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74994-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New tech D&D-seq maps DNA-protein interactions in single cells, revealing insights on TF binding and chromatin states, bridging gaps in gene expression control! PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how quasisymmetric one-component protein nanocages can revolutionize biologics delivery with virus-like assemblies of 100s-1000s of subunits! 🚀 PMID:42162430, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10554-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New Nature paper reveals replication stress causes chromatin loops to form, enclosing stalled forks at CTCF motifs, aiding genome integrity; join the convo! PMID:42386978, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10695-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

African proteomic study unlocks Alzheimer's insights. Nigerian and Tanzanian cohorts reveal plasma profiles linked to amyloid pathology; breakthrough in ADRD research! PMID:42386726, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74971-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Boost T cell therapy! Targeting CD2/CD7 increases nanoparticle delivery to CD4+ T cells—significantly higher uptake versus CD3/CD28. Transforming treatments! PMID:42386746, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74981-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

LEAPER 3.0 enhances RNA editing via engineered ADAR-recruiting RNAs. It leverages AlphaFold 3 for precision, expanding efficient editing strategies. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering a Buchnera protein key for host cell colonization boosts understanding of endosymbiont entry and immune suppression in insects! PMID:42386962, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10711-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovering the Plasmodium moving junction structure unveils a sailboat-shaped 1:1:1:1 assembly of PfAMA1 with PfRON2, PfRON4, and PfRON5, crucial for malaria invasion! PMID:42379167, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00699-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Heat stress increases susceptibility to metabolic dysfunction in mice on an obesogenic diet. Elevated skin-derived KLK14 affects hypothalamic LRRC7+ astrocytes. PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel model reveals mammalian cortical connectomes exhibit ⌀ topology influenced by physical constraints, focusing connectivity into distinct regions. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new method, variant in situ sequencing (VIS-seq), measures effects of ~3,000 LMNA & PTEN variants, revealing complex, high-dimensional phenotypes in cell architecture. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear metabolism links to gene regulation: ACO2 & IDH2 localize in the nucleus, catalyzing α-ketoglutarate reductive carboxylation for histone acetylation & gene activation. PMID:42386731, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74786-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Synthetic mRNA with N⁴-Acetylcytidine boosts translation yield, fidelity, and stability. Outperforms standard m¹Ψ in cancer and infection treatments. PMID:42386968, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10729-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights: Coccidioides arthroconidia activate TLR2 and induce NLRP3-pyrin inflammasomes in macrophages. Ferroptotic signaling aids fungal killing. Stay informed! PMID:42386736, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-75022-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transposable elements shape our genome by associating with epigenomic marks across 4867 ChIP datasets, influencing regulatory roles in various cell types. PMID:42386716, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74920-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk >5 years pre-diagnosis, enhancing prevention efforts beyond the CANTOS trial's NNT limitations. #CancerResearch PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A GWAS on 382 Hispanic newborns revealed 6 significant loci for 24 neonatal blood traits, highlighting chromosome 2p11.2's CD8A. #Genetics PMID:42385717, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S000292972600234X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪