Scientists find S. cerevisiae can help reduce vulvovaginal candidiasis severity by modulating fungal virulence and immune response, impacting millions globally. PMID:42362572, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74733-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals two clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats. One clade binds human ACE2, raising concerns for potential zoonotic spillover. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Stroke impacts 15M annually; 5M are left disabled. New randomized trial uses VR and neurostimulation for recovery. 🧠✨ PMID:42362865, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04486-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Developed D&D-seq for single-cell mapping of regulatory DNA-protein interactions, revealing insights on TF binding dynamics, chromatin accessibility, and gene expression! PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research maps 379 cell types across whole mouse sections using 59M single cells, enabling spatiotranscriptomics and machine learning for vital biomedical insights! PMID:41903540, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Early-stage Alzheimer’s model: 5xFAD mice show cognitive inflexibility before memory issues, with hyperactive corticostriatal circuits and striatal cholinergic dysfunction. PMID:42362551, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74817-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Ferroptosis inhibition enhances graft function in liver and lung transplants. FXT-001 targets early lipid peroxidation post-ischemia-reperfusion injury. Key! PMID:42105762, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00459-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative design of G_i-biased CB1 agonists, LZD503 & LZD505, targets pain relief while minimizing side effects, paving the way for safer non-opioid therapies. PMID:41980782, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00287-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative evolution model replays 100+ monoclonal germinal center reactions, revealing that B cell competition drives affinity increases in antibody evolution. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Allergens trigger PAR1-dependent ferritinophagy in lung epithelial cells, raising labile iron levels essential for protease-independent GSDMD activation, fueling IL-33 secretion. PMID:42361797, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00653-7 #Medsky #Pharmsky #RNA #ASHG 🧪

UPRmt in human microglia disrupts neuron-glia communication & promotes cell aging, revealing new insights into brain stress. PMID:42362883, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02320-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights show that vulnerable motor neurons in ALS shift to a unique "disease-associated" state marked by thousands of molecular changes before cell death. 📉🔍 PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

#JenniferDoudna’s team discovered #VIPR, a pre-CRISPR viral #RNA-guided system that uses an ancestral RAMP protein and a noncontiguous "1-nt skip" pairing code (NN-x-NN) for PAM-free programmable gene repression. 🧬🤖 #Science2026 #CRISPR #UCBerkeley #GeneEditing

Discover how dynamic ACh signaling in the BLA, crucial for salience processing, links to NAc: D1 neurons promote & D2 neurons suppress! PMID:42362886, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02353-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Just made it to Crete, Greece - not to discuss the law's of Zues, but to discuss tRNAs at the 30th tRNA conference.
#tRNA #RNA #PhD

A new AI framework identifies GPNMB as a promising CAR T target across melanoma, leukemia, and colorectal cancer, tackling the challenge of safe therapeutic design. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, integrating gene regulatory networks with RNA velocity to reveal 100+ candidate regulators that shape cell fate transitions. Exciting advancements! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 186 monoclonal antibodies from 28 aPAP patients reveals GM-CSF autoantibody affinity and epitope, not total titer, link to disease severity. Insights could advance treatments. PMID:42362542, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74717-2 #Medsky #Pharmsky #RNA 🧪

Real-time imaging of ErbB receptors using upconverting nanoparticles reveals that oncogenic EGFR mutations lead to stable, ligand-independent dimerization, shedding light on activation dynamics. PMID:42054992, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00399-5 #Medsky #RNA 🧪

A phytoscreen of 43 fruits and veggies reveals garlic as a strong deterrent of mating and egg-laying in Drosophila, with diallyl disulfide leading the way! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪