2 keynote speakers. 2 unique perspectives. 1 virtual symposium.
Join us Sept. 24-25 to hear from Ankit Malhotra, PhD, & Gareth Hawkes, PhD, on the growing impact of AI in #humangenetics.
🎓Earn up to 6 CE / 6 CEU for #geneticcounselor credits
Register: https://bit.ly/4pLrGt7 #ASHG #AI

Factors associated with 15% progression from AU to CU remain unclear. A systematic review highlights evidence gaps and uncertainty. PMID:42340685, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.1901 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how Ral GTPases bridge cholesterol to LDLR turnover! Insights from high-cholesterol diets unravel crucial liver cholesterol homeostasis mechanisms. PMID:42343138, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10697-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk 5+ years before diagnosis, enhancing prevention strategies post-CANTOS trial. Key for molecular cancer prevention! PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleogenomes from 12 cave lions over 100,000 years reveal distinct evolutionary paths and unique traits, with evidence of ancient gene flow into modern lions. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

FDA approves drugs despite only ~50% having ≥2 robust trials. Gepirone’s journey highlights lenient regulation with multiple contrasting studies. #DrugEfficacy PMID:42340691, JAMA Psychiatry 2026, @JAMAPsych @Stanford https://doi.org/10.1001/jamapsychiatry.2026.1438 #Medsky #Pharmsky #RNA #ASHG 🧪

Systematic CRISPR screens in primary CD4+ T cells revealed 12 potent anti-HIV host factors, highlighting diverse mechanisms that may aid therapeutic strategies. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel CRISPR-Cas9 mouse library with 84 gene-modified lines enhances influenza A virus research, bridging in vitro findings to whole-animal functional validation. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear envelope budding (NEB) facilitates the export of large transcripts in muscle cells during myoblast differentiation into myotubes, revealing a novel export pathway. PMID:42034051, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00386-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Promising results from a phase 1 trial of CAR T cells in recurrent GBM show tumor reduction & longer survival, but relapses persist. Key immunological insights revealed! PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover a spatiotemporal atlas of developing human hearts (8-15 weeks). Explore how genes coordinate ventricular growth across 30 sections. Ready to dive deeper? PMID:42336864, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74476-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Frequent prion-based switching of DNA repair proteins in S. cerevisiae allows dynamic control of mutagenesis, enhancing rapid adaptation across diverse environments. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

195 drugs, 98 indications: FDA approvals from 2015-2023 show female-predominant therapies get 1.5x more approvals than male ones. Clinical focus reflects this gender-driven need. PMID:42336860, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74469-z #Medsky #Pharmsky #RNA #ASHG 🧪

Transposable elements (TEs) shape mammalian genomes, affecting 50% of them! New studies reveal TEs' regulatory roles at specific loci, influencing gene expression and evolution. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG 🧪

Breakthrough in DMD treatment: Circ-arRNA tech achieves long-term exon skipping, restoring muscle function in monkeys & humans. Potential game-changer in gene therapy! PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

TOMORROW: September Journal Club webinar!
Join this discussion on responsible biomedical data sharing—balancing discovery with ethical, legal, & social considerations. Register now to hear from Maya Sabatello and Ellen Wright Clayton: https://bit.ly/45nniah @ajhgnews.bsky.social #ASHG

A novel genetic system uncovers 4 distinct pathways for neuronal protein clearance in the brain, revealing 2 hotspots for drainage previously overlooked in standard tracer studies. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG 🧪

About 50% of fertilized eggs fail during human pre-implantation due to error-prone 2nd mitotic divisions. Stochastic centriole overduplication can be reduced by PLK4 inhibition. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA #ASHG 🧪

Exciting advances in RNA editing with LEAPER 3.0 utilize engineered ADAR-recruiting RNAs for precise editing, integrating AlphaFold 3 for improved efficiency. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exploring acetylcholine's diverse roles in the hippocampus from novelty to error correction. A new predictive lens emerges. 🌟 PMID:42337376, Nat Rev Neurosci 2026, @NatRevNeurosci https://doi.org/10.1038/s41583-026-01058-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪