New findings reveal MAP1B, a microtubule-associated protein, shuttles to the nucleus in neural stem cells, linking cytoskeletal dynamics to cellular fate and disease. Fascinating! PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A new deep learning framework, Deep-Phase, links biomolecular condensate morphology to biochemical alterations, revealing how drugs affect cellular organization. #Biomedicine PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@hggadvances.bsky.social latest article shows that long-read sequencing aligned to the T2T-CHM13 reference genome improves variant detection across the β-globin locus in Africans with sickle cell disease: https://www.cell.com/hgg-advances/fulltext/S2666-2477(26)00109-0 #ASHG #HumanGenetics

RGS22 is crucial for metazoa-specific ciliary function. Mouse Rgs22 deficiency disrupts cilia coordination. This evolution aspect is key for tissue-wide flow! PMID:42342706, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74801-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Authors of @ajhgnews.bsky.social latest paper suggest a mechanism for sex-specific penetrance in Pilarowski-Björnsson syndrome (PILBOS), a neurodevelopmental disorder caused by CHD1 variants: https://www.cell.com/ajhg/fulltext/S0002-9297(26)00306-X #ASHG #HumanGenetics

Nuclear envelope budding (NEB) enables export of large transcripts in muscle cells during differentiation into myotubes, revealing a crucial pathway for handling large cargoes. PMID:42034051, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00386-7 #Medsky #Pharmsky #RNA #ASHG 🧪

Polyploidy drives evolution in angiosperms but is rarely ancient. A study of 470 species identified 132 dated WGD events, revealing non-random clustering patterns. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal that p53 is crucial in regulating human somatic cell reprogramming, balancing efficiency and safety amid potential oncogenic risks. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

700M face hunger, 2B lack nutrients. Boost yield, vitamins, minerals & climate resilience now!… PMID:42342872, Nature 2026, @Nature @OTSociety @NAR_Open https://doi.org/10.1038/s41586-026-10593-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mice exposed to heat stress showed 30% higher risk of metabolic dysfunction on an obesogenic diet, linked to KLK14's impact on hypothalamic LRRC7+ astrocytes. PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Man in 40s with congenital erythematous plaques on left limb evolving to warty lesions. Diagnosis: epidermal nevus. Thoughts? PMID:42340707, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.0809 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transformative research offers a spatiotranscriptomics atlas of the mouse, mapping 379 cell types from 59M single cells, paving the way for breakthroughs in biomedical science. PMID:41903540, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4 #Medsky #Pharmsky #RNA #ASHG 🧪

New study on Neanderthal genetics from 27 samples in Meuse Basin, Belgium reveals insights into late Neanderthal genetic diversity and social structure. 27! PMID:42343123, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10625-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals ecDNAs attach via H3K27ac-marked chromatin in mitosis; disruption … PMID:42342951, Nat Cell Biol 2026, @NatureCellBio @OTSociety @NAR_Open https://doi.org/10.1038/s41556-026-01982-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New method creates small-molecule binding proteins from scratch with high accuracy using dual neural networks in iterative design. Promising leap in drug design! PMID:42343133, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10670-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

KRAS farnesylation at C185 drives liquid-liquid phase separation, forming cytoplasmic condensates linked to advanced colon cancer and poor outcomes.👨‍⚕️🧬 PMID:42202789, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00519-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals the spatial organization of olfactory receptors in mice, highlighting 100+ distinct ORs mapped in the MOE & OB via MERFISH, crucial for social odor detection. PMID:42054995, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00389-2 #Medsky #Pharmsky #RNA #ASHG 🧪

Fusobacterium periodonticum in colorectal patients correlates with increased decanoic acid, driving neutrophil chemotaxis and tumor growth. Metagenomics & metabolomics reveal links. PMID:42342666, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74591-y #Medsky #Pharmsky #RNA #ASHG 🧪

2 keynote speakers. 2 unique perspectives. 1 virtual symposium.
Join us Sept. 24-25 to hear from Ankit Malhotra, PhD, & Gareth Hawkes, PhD, on the growing impact of AI in #humangenetics.
🎓Earn up to 6 CE / 6 CEU for #geneticcounselor credits
Register: https://bit.ly/4pLrGt7 #ASHG #AI

Factors associated with 15% progression from AU to CU remain unclear. A systematic review highlights evidence gaps and uncertainty. PMID:42340685, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.1901 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪