Prime editing modifies large DNA up to 570 bp efficiently, bypassing double-strand breaks and leaving no residual sequences—genome engineering redefined! PMID:42328791, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag626 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

TtAgo's DNA cleavage now works at 37–60°C! dCTP & TthSSB enable this leap for microRNA detection. A step forward from the old 65–85°C dependence! PMID:42331829, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74731-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New LEAPER 3.0 enhances RNA editing using engineered arRNAs that recruit ADARs efficiently. AlphaFold 3 integrates structural insights for precise editing. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

B cell deficiency hampers exercise capacity by reducing TGF-β1, disrupting liver glutamate metabolism, and lowering blood/muscle glutamate levels. Exciting findings! PMID:41999743, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00340-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Groundbreaking study shows LEAPER 2.0 using circular arRNA achieves long-term exon skipping in DMD, improving muscle function in monkeys & humans! #DMD #GeneEditing PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

50F presents with unique vasculitis case: subacute asymmetric weakness, severe pain, dysarthria, bilateral hypoglossal palsy. PMID:42329644, JAMA Neurol 2026, @JAMANeuro https://doi.org/10.1001/jamaneurol.2026.1901 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how over 4M cells & 5,000 clusters in mouse brain atlases reveal insights into cellular diversity! Ensures replicability in single-cell & single-nucleus datasets. PMID:42331798, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74171-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CHD1L promotes genome integrity by aiding Okazaki fragment maturation. Essential roles in DNA repair during replication! PMID:42328796, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag606 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪