New technologies, innovative partnerships, and bold ideas await at #ASHG26.

Register now to explore Industry Education and CoLab Sessions, discover emerging solutions, and build a personalized meeting experience: https://ashgmeeting.ashg.org/attend/register/ #ASHG #HumanGenetics

10-year study: CAR T-cell therapy, CTL019, shows promise for relapsed B-cell lymphomas in 38 patients (24 large, 14 follicular). Retweet for insights! PMID:42341302, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2518035 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover: Streptomyces encodes a megacluster for synergistic antibiotics! New genetic insights into coordinated multi-metabolite systems. Nature's innovation at its finest. PMID:42343126, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10647-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Frequent prion-based switching of DNA repair proteins boosts mutagenesis rates in S. cerevisiae, enhancing rapid adaptation across diverse environments. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough in gene control: An EMF-inducible gene switch enables precise in vivo gene expression activation via Cyb5b, revealed through CRISPR-Cas9 screening! PMID:41985457, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00330-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals a co-culture system enabling embryonic stem cells (ESCs) to mimic primitive streak formation, highlighting extra-embryonic tissues' crucial role in human development. PMID:42341759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00645-8 #Medsky #Pharmsky #RNA #ASHG 🧪

Get the insider guide before attending #ASHG26. Register for our Know Before You Go webinar (Oct. 7, 12 pm U.S. ET) to hear practical tips on navigating the meeting, planning your schedule, finding key resources, and making the most of your time on site: https://bit.ly/3VdApJ3 #ASHG

Study reveals >1,000x sequencing of 311 AD brain samples shows cancer driver sSNVs in microglia-like cells, linking clonal hematopoiesis to neuroinflammation. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Developed SPAC-seq and TARDIS, enabling high-throughput spatial CRISPR screens. Achieved insights into gene perturbations, linking 100+ genes to spatial phenotypes! PMID:42190664, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00516-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Engineered granulocyte-monocyte progenitors (GMPs) can now be expanded long-term for tumor immunotherapy, preserving identity and potential. Myeloperoxidase regulates GMP growth. PMID:42320470, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00643-4 #Medsky #Pharmsky #RNA #ASHG 🧪

Randomized trial (N=300) finds online team-based care for AD matches in-person treatment in reducing disease severity across 8 clinics! 🤝✨ PMID:42340708, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.1959 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study decodes 60,803 spectra from 1,000+ samples uncovering 8,746 unique protein substitutions in humans, shedding light on translational deviations. PMID:42343131, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10678-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough in rare disease diagnostics! Talos: automated genomic reanalysis tool boosts diagnostic yields with precision. Open-source & scalable. #Genomics PMID:42343115, Nat Med 2026, @NatureMedicine @broadinstitute https://doi.org/10.1038/s41591-026-04477-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

B cells enhance exercise capacity by secreting TGF-β1, which reprograms hepatic glutamine metabolism via GLS2 and SLC7A5, preserving muscle glutamate for ATP production! PMID:42208497, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00513-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how PUS1 and mtIF2 drive assembly of human mitoribosomal small subunits, crucial for mitochondrial translation, vital for cell energy—key to tackling diseases! PMID:42342677, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74700-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore STING's mutational impact on immunity, revealing interplay of structural changes, interactions, and trafficking crucial for host defense and inflammation. PMID:42343134, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10685-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New Nature study uncovers small molecules directly modulating β-arrestins, key players in GPCR signaling. A leap forward in therapeutics! PMID:42343124, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10683-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

GLP-1 receptor agonists are used by 34% of people with eating disorders; misuse found in 12%. Discuss the implications! PMID:42340738, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1716 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings reveal MAP1B, a microtubule-associated protein, shuttles to the nucleus in neural stem cells, linking cytoskeletal dynamics to cellular fate and disease. Fascinating! PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG 🧪

A new deep learning framework, Deep-Phase, links biomolecular condensate morphology to biochemical alterations, revealing how drugs affect cellular organization. #Biomedicine PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪