New research shows heat stress in mice elevates KLK14, leading to metabolic dysfunction on an obesogenic diet. Heat stress affects 1 in 3 mice’s metabolic health! PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host gut metabolism using its Bacteroides fragilis toxin, fostering an oxidative environment that promotes its growth amid inflammation. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals VPS13A's complex with scramblase XK, highlighting their roles in vesicle-independent lipid transfer across organelle contact sites. Insightful collaboration! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A Hadean timeline for the emergence of the RNA World
#OriginsOfLife #RNAworld #RNA #scienceSky

www.nature.com/articles/s41...

Engineered ADAR-recruiting RNAs (arRNAs) boost RNA editing by leveraging endogenous ADAR, with LEAPER 3.0 enhancing precision via AlphaFold 3 insights. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A variant (rs17437411) in the HOXA gene locus links to reduced blood counts, cancer protection, and impacts on human hematopoietic stem cells via a novel lncRNA, HOXA opposi. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

First for #RNA therapy: man with rare motor neuron disease improves after treatment
#Health #Science

Largest proteogenomic study (n=78,664) reveals >24,000 protein QTLs linked to 1,116 proteins, uncovering pathways and genetic effects on disease mechanisms. PMID:42097137, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00385-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study links autoantibodies (AABs) to neurological symptoms in long COVID, revealing AABs against CNS and PNS proteins in patients—suggesting a causal role. PMID:42208499, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600509X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Enterotoxigenic Bacteroides fragilis (ETBF) rewires host metabolism using its toxin to thrive in the inflamed gut, revealing potential targets for colitis and cancer prevention. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG 🧪

Autoantibodies against type-I interferons (AAN-I-IFNs) are key in severe viral infections like life-threatening COVID-19, revealing diverse B cell responses even before severe symptoms. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky #RNA 🧪

Another collaboration published! Have a look at this work on targeting TERRA RNA G-quadruplexes with small molecules and their role in ALT-associated telomere maintenance.

Full text: onlinelibrary.wiley.com/doi/epdf/10....

#RNA #GQuadruplex #Targeting #NMR

Exciting findings in human meninges development! Single-cell transcriptomics reveals asynchronous layer formation, with pia mater emerging by 6 GW. Layer-specific fibroblast states defined! Let's discuss! PMID:42214341, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00507-6 #RNA 🧪

🧬 RNA molecules can carry chemical structures known as caps at their 5′ end. These caps affect RNA stability, processing and function...

🧵

#RNA #RNAcaps #UOCHB #IOCB #IOCBPrague #czechscience #chemistry #biochemistry #research

In Lactobacillus casei, the AUA codon is decoded predominantly by tRNA-Ile(UAU), whereas lysidine-containing tRNA-Ile(LAU) contributes little because of its low aminoacylation level #RNA #tRNA bit.ly/3UmlWua

🧠🦋💫Please share! Ambitious young scientist? Multiple
@ERC_Research #postdoc #opportunities in #RNA #DirectedEvolution #GenomeEditing #FitnessLandscapes #Bioengineering #MachineLearning at @GOLDLab_UCD. Full details here: www.gold-lab.org/we-are-hiring

A novel method, VIS-seq, measures diverse phenotypic effects of ~3,000 LMNA & PTEN variants, revealing complex impacts on protein activity and cell structure. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel non-invasive genetic system reveals unique drainage routes for neuron-derived proteins from the brain to CSF, uncovering overlooked clearance hotspots. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

TransCode Therapeutics Makes Significant Patent Advances in Australia and Japan for RNA-Based Cancer Therapies #None #Immuno-Oncology #TransCode #RNA

Cisplatin, a cancer treatment, induces neurotoxicity. NER helps neurons remove DNA damage but paradoxically leads to cell death. Understanding this may aid neuroprotection. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪