Discover hidden links: ATP synthase connects beyond complex II in OXPHOS-TCA interaction using XL-MS, mapping numerous crosslinks. Metabolic insight redefined! PMID:42337254, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74730-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

SNIPSNP: Optimize CRISPR/Cas9 HDR edits! Simplifies Cas9 re-cleavage, handles complex in… PMID:42333535, Nucleic Acids Res 2026, @NAR_Open @OTSociety @NAR_Open https://doi.org/10.1093/nar/gkag409 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Single-cell RNA sequencing shows endothelial & mesenchymal stem cells undergo transcriptional changes from MGUS to MM. Key shifts reveal non-immune role in BME. PMID:42336819, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74389-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

D&D-seq enables single-cell profiling of weak/transient DNA-protein interactions, enhancing understanding of TF binding dynamics and gene regulation. #ScienceInsights PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals that MAP1B, a microtubule-associated protein, shuttles to the nucleus of neural stem cells, linking cytoskeletal dynamics to cellular fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel CRISPR-Cas9 mouse library of 84 gene-modified lines transforms influenza A research, bridging in vitro findings with in vivo validations, unlocking new insights! PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Acute SARS-CoV-2 infection leads to functional autoantibodies (AABs) in long COVID, with neurocognitive symptoms linked to elevated AABs against CNS and PNS proteins. PMID:42208499, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600509X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A comprehensive MERFISH analysis reveals the spatial mapping of olfactory receptor expression in the MOE and OB, crucial for detecting social odors in mice. PMID:42054995, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00389-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Autoantibodies in a subset of long COVID patients may directly cause symptoms including pain, fatigue, and cognitive issues, highlighting 2 new studies' critical insights. PMID:42208496, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00511-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Ancient DNA preserved in pigments from 24 rock art panels across 11 caves in Spain and Portugal links Palaeolithic creators to their artwork. PMID:42336828, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74234-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study links HRD in high-grade ovarian cancer with pathogenicity of BRCA1/2 variants, enhancing classification in 250+ cases! #CancerResearch PMID:42335889, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S0002-9297(26)00225-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover jumbo extrachromosomal elements: up to 535kb size, link to Methanoperedens a… PMID:42337238, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74423-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting insights from cryo-EM reveal the 2:4:2 Wnt3a/Fzd8/LRP6 complex, showcasing a Wnt3a homodimer essential for activating Wnt/β-catenin signaling! PMID:42202788, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00523-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Large cohort analysis (1409 participants) reveals Saccharomycetes & Malassezia link gut mycobiome maturation to allergy risk in childhood via interkingdom dynamics. PMID:42337243, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74418-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study of 78,664 participants revealed >24,000 protein QTLs linked to 1,116 proteins, uncovering genetic regulation insights across pathways and cell types. PMID:42097137, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00385-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover 20 new noncanonical CYP families lacking a typical cysteine ligand in microbial genomes! 🌍🔬 Breakthrough in enzyme biology. #CYPinnovation PMID:42332020, Nat Chem Biol 2026, @nchembio @Princeton https://doi.org/10.1038/s41589-026-02235-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/veggies reveals garlic as a powerful deterrent against mating/egg-laying in Drosophila. Diallyl disulfide inhibits these behaviors! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Prime editing modifies large DNA up to 570 bp efficiently, bypassing double-strand breaks and leaving no residual sequences—genome engineering redefined! PMID:42328791, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag626 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

TtAgo's DNA cleavage now works at 37–60°C! dCTP & TthSSB enable this leap for microRNA detection. A step forward from the old 65–85°C dependence! PMID:42331829, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74731-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New LEAPER 3.0 enhances RNA editing using engineered arRNAs that recruit ADARs efficiently. AlphaFold 3 integrates structural insights for precise editing. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪