Long-term SPT of EGFR, HER2, and HER3 reveals oncogenic EGFR mutations induce stable, ligand-independent dimerization, impacting ErbB signaling dynamics significantly. PMID:42054992, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00399-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting findings reveal human meninges develop asynchronously from 6-23 gestational weeks, with pia mater emerging first. Layer-specific fibroblast states identified! PMID:42214341, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00507-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Introducing CANVAS: an AI platform that decodes tumor microenvironments from H&E histopathology, using insights from 18M+ cells to enhance understanding of TME. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

@hggadvances.bsky.social sat with Carissa Sherman, PhD, and Betzaida Maldonado in the latest "Inside HGGA" to discuss their recently published paper, “Underrepresented Voices in a Colorado Biobank.”➡️ https://bit.ly/4r7swB4 #ASHG #HumanGenetics #GeneticsDiscoveries

Unbiased SAMENT labels immune-excluded niches in bone metastasis, revealing common traits like macrophage enrichment (3x) & T cell depletion (2x) across cancers! PMID:42054994, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00398-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 2457 patients with TNBC shows 10% relapse after pathological complete response post-neoadjuvant treatment. 1192 achieved complete response. Can immune markers predict risk? PMID:42343076, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74056-2 #Medsky #Pharmsky #RNA #ASHG 🧪

Explore the cryo-EM structure of Rad26/CSB-nucleosome complex. Discover its crucial role in TC-NER, binding RNA polymerase II & remodeling nucleosomes. PMID:42342665, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73500-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Analyzing blood proteomics can unearth why 40-60% of cancer patients resist immune checkpoint therapy. Early detection may optimize treatment and reduce toxicity. PMID:42342704, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74790-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Late embryonic skin injuries in mammals can regenerate diverse cell types, but this ability diminishes post-birth, leading to hyperinnervation and impaired healing. 🧬💔 PMID:41864207, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00234-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI in medicine can boost diagnostics, but privacy risks loom. Patient info in training data may leak, with multiple similar records at risk. Stay informed! PMID:42343130, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10688-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New Gi-biased CB1 agonists LZD503 & LZD505 show promise as next-gen non-opioid therapies, minimizing adverse effects through smart structural tuning. PMID:41980782, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00287-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover precise image-guided drug activation for personalized medicine using electromagnetic radiation from γ-rays to IR light! PMID:42342845, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02248-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, a game-changing framework integrating gene regulatory networks with RNA velocity analysis to identify candidate regulators influencing cell fate changes. PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG 🧪

Two studies in Cell reveal that olfactory receptors are organized in continuous gradients, not zones, linking receptor choice to axonal targeting via a molecular code. PMID:42208495, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00510-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study on 1432 psychosis patients finds distinct neurometabolite profiles linked to antipsychotic response, guiding better treatments. PMID:42340705, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1674 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals the 2:4:2 structure of Wnt3a/Fzd8/LRP6 complex, showing Wnt3a homodimer binding crucial for activating Wnt/β-catenin signaling. Exciting insights! PMID:42202788, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00523-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovered small-molecule activators of PAK1, crucial for cardiac health, by targeting an autoinhibition-release site. A breakthrough in kinase activator development! PMID:41923641, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00275-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

CMS introduces a payment model linking AI-driven behavioral health care to outcomes, potentially revolutionizing care delivery. PMID:42340690, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1681 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/veg revealed garlic as a top choice for deterring mating & egg-laying in Drosophila. Diallyl disulfide is the key compound! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New technologies, innovative partnerships, and bold ideas await at #ASHG26.

Register now to explore Industry Education and CoLab Sessions, discover emerging solutions, and build a personalized meeting experience: https://ashgmeeting.ashg.org/attend/register/ #ASHG #HumanGenetics