NAD+ modulates mitochondrial vulnerability in MERTK models of retinitis pigmentosa (R… PMID:42365006, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74400-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Major breakthrough in HIV research: CRISPR screens in primary CD4+ T cells identified multiple pro- and anti-HIV host factors, revealing diverse antiviral mechanisms! PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1 to sense singlet oxygen (¹O₂) and trigger photoprotection, revealing how plants manage high-light tolerance through protein condensates. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/veggies reveals garlic as a potent inhibitor of mating & egg-laying in Drosophila. Diallyl disulfide shows promise in pest control! 🧄✨ PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study of 311 AD brains found somatic single-nucleotide variants (sSNVs) enriched in cancer driver genes, linked to clonal hematopoiesis and microglia-like cells, driving inflammation. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA 🧪

Intranasal boost in female mice primed with Wuhan-1 spike mRNA or ChAd vaccines enhances variant-specific antibodies, addressing immunity evasion in emerging SARS-CoV-2 variants. PMID:42364994, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74762-x #Medsky #Pharmsky #RNA #ASHG 🧪

Revolutionizing neuroscience, a new trimodal platform reveals Ca²⁺ dynamics, morphology, and gene expression in single neurons for enhanced understanding of neuronal functions. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG 🧪

Chronic suppression of MDR Pseudomonas aeruginosa in a prosthetic joint infection achieved via personalized bacteriophage treatment after antibiotics failed! PMID:42364990, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74326-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

🗣️ IOCB Prague hosted the 2026 edition of #RNAClub last week.

The annual meeting brought together more than 100 scientists to IOCB Prague for a day of scientific talks, poster presentations, and discussions ► www.uochb.cz/en/news/827/

#biochemistry #praguelectures #RNA

A novel LLM-assisted scoring framework identifies GPNMB as a promising CAR T target in melanoma, leukemia, and colorectal cancer, addressing a key bottleneck in therapy. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies TMEM154/Galvanin as a key receptor enabling cells to sense electric fields (≤ 100 mV/mm) and migrate toward the cathode. Exciting times! PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

D-SPIN reconstructs gene regulatory networks from single-cell RNA-seq, revealing how cells maintain homeostasis and respond to perturbations, enhancing understanding of cell-state transitions. PMID:42127893, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00463-0 #Medsky #RNA 🧪

Revolutionizing spermatogenesis studies, 2,653 genes in 867,062 mouse testis cells reveal dynamic cycles in Sertoli cells, aligning transcription with germ-cell differentiation. PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Aging male mice show disrupted water balance/thermoregulation: AVP neurons in hypothalamus are key. RNA-seq finds Avp upregulated. Old neurons enlarged, more excitable. PMID:42364986, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74819-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A variant (rs17437411) in the HOXA locus lowers blood counts, protects against blood cancers, and alters phenotypes, linked to a new lncRNA, HOXA opposi. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive vascular integrity in small-cell lung cancer leads to immune desertification. Wang et al. propose "reverse normalization" to enhance immunotherapy efficacy. PMID:42349379, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00634-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research shows heat stress in mice elevates KLK14, leading to metabolic dysfunction on an obesogenic diet. Heat stress affects 1 in 3 mice’s metabolic health! PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host gut metabolism using its Bacteroides fragilis toxin, fostering an oxidative environment that promotes its growth amid inflammation. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals VPS13A's complex with scramblase XK, highlighting their roles in vesicle-independent lipid transfer across organelle contact sites. Insightful collaboration! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A Hadean timeline for the emergence of the RNA World
#OriginsOfLife #RNAworld #RNA #scienceSky

www.nature.com/articles/s41...