Exciting progress in CB1 drug design! Two Gi-biased agonists, LZD503 and LZD505, show promise for reducing side effects, enhancing non-opioid therapy. PMID:41980782, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00287-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore severe pneumonia: 3 distinct lung-restricted sub-phenotypes identified via bronchoalveolar transcriptomics, cytokines, and microbiology in critical care patients. PMID:42337236, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74190-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The study reveals that mycobacteria use Type VII-secreted toxins for inter-bacterial competition, thanks to GH183 family endo-D-arabinanases, despite their robust cell walls! PMID:42336839, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74429-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AAN-I-IFNs+ patients with severe COVID-19 show a stable, diverse B cell response that neutralizes type-I interferons, indicating a connection to T cell tolerance defects. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research shows that mRNA 3' UTRs impact protein activity for 3 important proteins (MYC, UTX, JMJD3) by co-translationally folding JMJD3's IDRs, enhancing function! PMID:42259285, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00576-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how Urolithin A selectively activates AHR in mouse intestinal epithelial cells, enhancing gut barrier and mucosal immunity. Potential breakthrough for IBD! PMID:42336837, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-73760-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk 5+ years pre-diagnosis, enhancing prevention beyond CANTOS' high NNT with IL-1β inhibition. PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel SPAC-seq platform enables spatial CRISPR screening, linking 1,000+ gene perturbations to tissue phenotypes, enhancing insights into signaling pathways. PMID:42190664, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00516-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel EMF-driven gene switch enables precise control of gene expression in vivo, using Cyb5b as a key mediator. This could revolutionize biomedical applications! PMID:41985457, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00330-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

12 cave lion genomes from over 100,000 years reveal distinct evolutionary lineages between modern and cave lions, showcasing unique variants and ancient gene flow. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover a novel biosensor! Detect biomolecules with ultrasensitivity using a dielectric metasurface with continuous geometry gradient. No spectrometer needed, just a camera. PMID:42336861, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74749-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Unlocking genomic potential: 1 genome→ 1 promise for health! Insights into rare diseases=3x better diagnostics & screening! #GenomicHealth PMID:42335890, Am J Hum Genet 2026, @AJHGNews https://www.cell.com/ajhg/fulltext/S0002-9297(26)00227-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study on 470 angiosperm species identifies 132 ancient WGD events, highlighting non-random clustering and polyploidy's dual role in evolution. Insights deepen! PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Phytoscreening 43 fruits/veggies revealed garlic as a top inhibitor of mating & egg-laying in Drosophila. Diallyl disulfide identified as key compound! 🌱🦟✨ PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore KT-474's precision: A study unveils the cryo-EM structure of an IRAK4:KT-474:CRBN/DDB1 complex, unlocking insights for immuno-inflammatory disease treatment. 🌟 PMID:42336816, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74105-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cuproptosis, a copper-dependent cell death, enhances antitumor immunity. CD8⁺ T cells boost tumor sensitivity to cuproptosis, making treatment more effective. PMID:42330950, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00636-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cas13's precision in RNA targeting expands CRISPR's potential beyond DNA, yet therapeuti… PMID:42333809, Nucleic Acids Res 2026, @NAR_Open @OTSociety @NAR_Open https://doi.org/10.1093/nar/gkag616 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

B cell deficiency reduces exercise capacity by lowering TGF-β1, disrupting liver glutamate metabolism, and diminishing blood/muscle glutamate. Key link found! PMID:41999743, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00340-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Groundbreaking genome-wide CRISPR screens in primary CD4+ T cells revealed numerous pro- and anti-HIV factors, uncovering diverse antiviral mechanisms. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover hidden links: ATP synthase connects beyond complex II in OXPHOS-TCA interaction using XL-MS, mapping numerous crosslinks. Metabolic insight redefined! PMID:42337254, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74730-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪