Research reveals that METHYLENE BLUE SENSITIVITY1 (MBS1), a zinc-finger protein, helps chloroplasts sense singlet oxygen (¹O₂) to boost photoprotection in high light. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals excessive vascular integrity in small-cell lung cancer creates an immune desert. "Reverse normalization" may boost immunotherapy efficacy—time to rethink strategies! PMID:42349379, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00634-3 #Medsky #Pharmsky #RNA 🧪

New study reveals mesenchymal drift as a unifying mechanism linking key aging hallmarks, showing how cells lose identity and adopt mesenchymal traits, fostering decline. PMID:42208498, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00455-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discovery of Galvanin (TMEM154) reveals its critical role in electric-field-guided cell migration, shedding light on how 40% of immune cells navigate to wounds. PMID:42127892, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00461-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Kongming defense uses a helical KomBC complex activated by dITP during phage attack. Structural analysis reveals KomB & KomC's role in antiviral action. 🧬🔍 PMID:42362564, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74710-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mapped the olfactory system in mice using MERFISH, revealing distinct expression patterns of 100+ olfactory receptors vital for social odor detection and processing. PMID:42054995, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00389-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals that cancer metastasis is influenced by specific microenvironments, showing 5 key niche traits like macrophage enrichment & T cell depletion. #CancerResearch PMID:42054994, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00398-3 #Medsky #Pharmsky #RNA #ASHG 🧪

CRISPR-Cas13a and HicAB synergy limits phages in E. coli, revealing bacterial defense… PMID:42362581, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74930-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A mini zine about My Infectious Diseases Life
Issue #37– teamwork, words I can’t forget, who’s the resilient here?, invaluable, PISCES!

*I’m traveling, and only have with me a few pens and markers, no glue or good lighting, but still gotta process the week that was

#IDSky #PharmSky #MedSky

Scientists find S. cerevisiae can help reduce vulvovaginal candidiasis severity by modulating fungal virulence and immune response, impacting millions globally. PMID:42362572, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74733-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research reveals two clades of SARS-CoV-2-related coronaviruses in Thai horseshoe bats. One clade binds human ACE2, raising concerns for potential zoonotic spillover. PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Stroke impacts 15M annually; 5M are left disabled. New randomized trial uses VR and neurostimulation for recovery. 🧠✨ PMID:42362865, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04486-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Developed D&D-seq for single-cell mapping of regulatory DNA-protein interactions, revealing insights on TF binding dynamics, chromatin accessibility, and gene expression! PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research maps 379 cell types across whole mouse sections using 59M single cells, enabling spatiotranscriptomics and machine learning for vital biomedical insights! PMID:41903540, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Early-stage Alzheimer’s model: 5xFAD mice show cognitive inflexibility before memory issues, with hyperactive corticostriatal circuits and striatal cholinergic dysfunction. PMID:42362551, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74817-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Ferroptosis inhibition enhances graft function in liver and lung transplants. FXT-001 targets early lipid peroxidation post-ischemia-reperfusion injury. Key! PMID:42105762, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00459-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative design of G_i-biased CB1 agonists, LZD503 & LZD505, targets pain relief while minimizing side effects, paving the way for safer non-opioid therapies. PMID:41980782, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00287-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Innovative evolution model replays 100+ monoclonal germinal center reactions, revealing that B cell competition drives affinity increases in antibody evolution. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Allergens trigger PAR1-dependent ferritinophagy in lung epithelial cells, raising labile iron levels essential for protease-independent GSDMD activation, fueling IL-33 secretion. PMID:42361797, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00653-7 #Medsky #Pharmsky #RNA #ASHG 🧪

UPRmt in human microglia disrupts neuron-glia communication & promotes cell aging, revealing new insights into brain stress. PMID:42362883, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02320-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪