Variant in situ sequencing (VIS-seq) reveals phenotypic impacts of ~3,000 LMNA and PTEN mutations, highlighting protein changes and cell architecture critical for disease study. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Neuronal state influences expression of psychiatric gene variants. A crucial piece for understanding mental health! 📘🧠 PMID:42348709, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aei6085 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Unveiling HIV secrets! Three immunoregulatory signatures in TSCM CD4⁺ T cells are key to non-productive HIV infection. A game changer in understanding HIV reservoirs! PMID:42350407, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74551-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study of 78,664 participants reveals >24,000 protein QTLs linked to 1,116 proteins, highlighting genetic influence on disease pathways and mechanisms. PMID:42097137, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00385-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals structures of human blue (OPN1SW) & green-sensitive cone opsins, aiding understanding of photopic vision mechanisms. PMID:42348698, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adz3624 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study reveals mapping of olfactory receptors in MoE & OB using MERFISH, showing how social odors influence mouse behavior. Key insights on 100+ ORs! PMID:42054995, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00389-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study: NEDD8 & SUMO2 regulate skin cell functions oppositely. Knockout mice reveal roles in homeostasis & inflammation, using multiomics. PMID:42348677, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aeb3900 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

D-SPIN uncovers gene regulatory networks from scRNA-seq data, revealing how cells maintain homeostasis and respond to perturbations. A breakthrough in understanding cell dynamics! PMID:42127893, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00463-0 #Medsky #Pharmsky #RNA #ASHG 🧪

Chloroplasts use MBS1, a conserved mediator with a ZnF domain, to sense singlet oxygen (¹O₂) and trigger photoprotection, enhancing high-light tolerance. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study: Single-cell multiomics of neuron activation across 100 donors reveals key genetic variants for neuropsychiatric disorders. PMID:42348686, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adw3949 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Transform lipid peroxidation: 4-ONE reprogrammed as a chemoselective crosslinker. Connects Cys-Lys, forming pyrrole linkage. Precision in oxidative stress chemistry! PMID:42350428, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74843-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Engineered AAV9 vector targets SOD1 mutations in ALS, extending mouse survival. Gene silencing through a single IV dose shows promise for durable ALS treatment. PMID:42350385, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74169-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Rational strategies led to the discovery of small-molecule activators of PAK1, unlocking a new autoinhibition-release site crucial for cardiac health! PMID:41923641, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00275-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF, an anaerobic pathogen, hijacks host metabolism to thrive in the inflamed gut, using Bacteroides fragilis toxin to reshape nutrient niches. Powerful insights into disease! PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG 🧪

New method D&D-seq enables single-cell profiling of transient DNA-protein interactions, revealing key insights into transcription factor dynamics in gene regulation. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exploring enzymatic recycling for nylon waste! Key barriers: biochemical, structural, materials science. Progress needed! PMID:42174226, Nat Chem Biol 2026, @nchembio https://doi.org/10.1038/s41589-026-02210-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionary approach using LEAPER 2.0 and circ-arRNAs achieved long-term exon skipping in DMD, showing promise in monkeys and humans for muscle recovery! PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A study reveals that 78% of long COVID patients produce autoantibodies targeting CNS proteins, correlating with neurocognitive symptoms, signaling a potential pathogenic role. PMID:42208499, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600509X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mammalian skin can regenerate diverse tissues after late embryonic injuries, but this ability diminishes post-birth, leading to hyperinnervation in wounds, limiting regeneration. PMID:41864207, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00234-5 #Medsky #Pharmsky #RNA #ASHG 🧪

Systematic CRISPR screens in primary CD4+ T cells identified 30+ pro/anti-HIV factors, revealing diverse mechanisms that could inform targeted therapies against HIV! PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪