Prion-based protein self-assembly enables rapid adaptive mutagenesis in Saccharomyces cerevisiae populations, altering DNA repair mechanisms for evolution. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

2'3'-cGAMP promotes membrane shearing, enhancing phage immunity via TM proteins in the CBASS system, revealing key antiviral mechanisms. PMID:41999741, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00344-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Introducing RegVelo: a novel framework that bridges gene regulatory networks and RNA splicing dynamics, enhancing insights into cellular fate transitions via deep learning! #RegVelo PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #Medsky #Pharmsky #RNA 🧪

“Targeted science for healthier futures.”

Discover emerging research across oligonucleotide therapeutics, RNA therapeutics, mRNA, and next-generation delivery at OTDC 2027.

May 11–12, 2027 | Boston, MA | In-Person & Virtual
🌐 oligo-nucleotide.com

#OTDC2027 #RNA #DrugDelivery #Biotech

Primate organogenetic embryoids from cynomolgus totipotent blastomere-like stem cells (cTBLCs) reveal crucial totipotent-like features, advancing embryonic development modeling. PMID:42269606, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00582-9 #Medsky #Pharmsky #RNA #ASHG 🧪

Transposable elements, making up nearly 50% of mammalian genomes, play key roles in shaping gene expression, evolution, and disease through locus-specific regulation. PMID:42276034, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00520-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New clades of SARS-CoV-2-related coronaviruses found in Thai horseshoe bats show ability to bind human ACE2; dynamic virology raises significant concerns! PMID:42097139, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600454X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel blood-brain barrier-like vascular gate in small cell lung cancer limits immune cell infiltration, explaining the poor immunotherapy response in SCLC. PMID:42102817, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00452-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, a groundbreaking tool that integrates gene regulatory networks with RNA velocity, identifying 7 key regulators influencing cell fate changes! PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study on 3,987,182 COVID-19 cases in Korea shows higher asthma risk post-infection for those with systemic atopy or upper-airway disease. Who else saw this connection? PMID:42364998, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74860-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Donor-derived CD19-CAR T cells show enhanced expansion & persistence vs. standard CAR T cells post-HSCT. TSCM cells yield complete responses at low doses, no lymphodepletion needed. PMID:42066750, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00383-1 #Medsky #Pharmsky #RNA 🧪

🧬🖥️ Built rnafold.com — run several structure-prediction engines and see what each produced, where they disagree, and
what the structures actually contain: base pairs, G-tetrads, pockets,
interfaces. Full provenance. Free. Works for RNA, DNA, proteins and small molecules!

#RNA #Bioinformatics

A recent study on CAR T cell therapy for recurrent GBM shows promising tumor reduction with prolonged survival, yet relapses remain common. Key insights reveal the importance of the immune environment in… PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #RNA 🧪

New research unveils a "disease-associated motor neuron" state in ALS, revealing 1000s of molecular shifts in SOD1-G93A model. Key insights on transcription factors emerge! PMID:42335888, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00647-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Predicting how #RNA folds would be a valuable tool for scientists, but #AI has not been able to crack the problem. A team at the IGI made significant progress on two key hurdles: limited structural data, and the fact that RNA can take on multiple shapes. Read more:
https://ow.ly/Yjgo50ZJcU3

CD8+ T cells utilize cysteine for glutathione (GSH) production, enhancing effector functions, and for sulfur in FeS cluster synthesis—crucial for T cell proliferation. NFS1 deletion leads to exhaustion… PMID:41923640, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00279-5 #RNA 🧪

A 14-protein plasma signature predicts lung cancer >5 years before diagnosis, enhancing prevention strategies beyond CANTOS NNT challenges. Notable for early detection impact! PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG 🧪

Seoul biotech’s redesigned method makes circular RNA up to seven times more efficient to build, widening what RNA medicine can treat.

Link as first comment.

#longevity #geroscience #circularRNA #RNA #biotech

Phenol carryover? Your RNA workflow doesn’t need it. 🧬
Norgen’s SiC technology enables a 100% phenol-free RNA purification workflow designed for reproducible extraction.
Skip the phenol. Focus on the RNA.
#RNAExtraction #PhenolFree #RNA #NorgenBiotek

Study reveals that targeting macrophage ferritin heavy chain (FTH1) can reduce ferroptosis and lung damage in ARDS. Elevated serum ex-ferritin ties to worse outcomes. PMID:42364999, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74828-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪