700M face hunger, 2B lack nutrients. Boost yield, vitamins, minerals & climate resilience now!… PMID:42342872, Nature 2026, @Nature @OTSociety @NAR_Open https://doi.org/10.1038/s41586-026-10593-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Mice exposed to heat stress showed 30% higher risk of metabolic dysfunction on an obesogenic diet, linked to KLK14's impact on hypothalamic LRRC7+ astrocytes. PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Man in 40s with congenital erythematous plaques on left limb evolving to warty lesions. Diagnosis: epidermal nevus. Thoughts? PMID:42340707, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.0809 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study on Neanderthal genetics from 27 samples in Meuse Basin, Belgium reveals insights into late Neanderthal genetic diversity and social structure. 27! PMID:42343123, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10625-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals ecDNAs attach via H3K27ac-marked chromatin in mitosis; disruption … PMID:42342951, Nat Cell Biol 2026, @NatureCellBio @OTSociety @NAR_Open https://doi.org/10.1038/s41556-026-01982-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New method creates small-molecule binding proteins from scratch with high accuracy using dual neural networks in iterative design. Promising leap in drug design! PMID:42343133, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10670-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

KRAS farnesylation at C185 drives liquid-liquid phase separation, forming cytoplasmic condensates linked to advanced colon cancer and poor outcomes.👨‍⚕️🧬 PMID:42202789, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00519-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Factors associated with 15% progression from AU to CU remain unclear. A systematic review highlights evidence gaps and uncertainty. PMID:42340685, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.1901 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how Ral GTPases bridge cholesterol to LDLR turnover! Insights from high-cholesterol diets unravel crucial liver cholesterol homeostasis mechanisms. PMID:42343138, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10697-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A 14-protein plasma signature predicts lung cancer risk 5+ years before diagnosis, enhancing prevention strategies post-CANTOS trial. Key for molecular cancer prevention! PMID:42242224, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00522-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleogenomes from 12 cave lions over 100,000 years reveal distinct evolutionary paths and unique traits, with evidence of ancient gene flow into modern lions. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Systematic CRISPR screens in primary CD4+ T cells revealed 12 potent anti-HIV host factors, highlighting diverse mechanisms that may aid therapeutic strategies. PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel CRISPR-Cas9 mouse library with 84 gene-modified lines enhances influenza A virus research, bridging in vitro findings to whole-animal functional validation. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Nuclear envelope budding (NEB) facilitates the export of large transcripts in muscle cells during myoblast differentiation into myotubes, revealing a novel export pathway. PMID:42034051, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00386-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Promising results from a phase 1 trial of CAR T cells in recurrent GBM show tumor reduction & longer survival, but relapses persist. Key immunological insights revealed! PMID:42296961, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00585-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover a spatiotemporal atlas of developing human hearts (8-15 weeks). Explore how genes coordinate ventricular growth across 30 sections. Ready to dive deeper? PMID:42336864, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74476-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Frequent prion-based switching of DNA repair proteins in S. cerevisiae allows dynamic control of mutagenesis, enhancing rapid adaptation across diverse environments. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough in DMD treatment: Circ-arRNA tech achieves long-term exon skipping, restoring muscle function in monkeys & humans. Potential game-changer in gene therapy! PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exciting advances in RNA editing with LEAPER 3.0 utilize engineered ADAR-recruiting RNAs for precise editing, integrating AlphaFold 3 for improved efficiency. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Exploring acetylcholine's diverse roles in the hippocampus from novelty to error correction. A new predictive lens emerges. 🌟 PMID:42337376, Nat Rev Neurosci 2026, @NatRevNeurosci https://doi.org/10.1038/s41583-026-01058-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪