B cell deficiency reduces TGF-β1 during exercise, impairing liver glutamate metabolism and decreasing blood/muscle glutamate, limiting exercise capacity. PMID:41999743, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00340-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cysteine's sulfur is crucial for T cell fate, directing 80% to glutathione and 20% to iron-sulfur clusters, vital for CD8⁺ T cell growth and anti-tumor immunity! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals p21+ senescent cells shape blood-brain and blood-CSF barriers in mice, with lifelong non-inflammatory states in choroid plexus supporting CSF production. PMID:42269604, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00581-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Where #humangenetics, genomics, & #AI meet: The Intelligent Genome: Powered by AI. From Sept. 24-25, join the experts turning AI's potential into practical applications across the field.🚨One week to go. Register now: https://bit.ly/4pLrGt7 #ASHG

MARCH7 identified as a key E3 ubiquitin ligase that safeguards against ferroptosis by regulating intracellular Fe homeostasis via NCOA4 ubiquitylation. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Neoadjuvant stereotactic body radiation therapy (3×8 Gy) with durvalumab and oleclumab shows promise in ER+HER2- early breast cancer. PMID:42350643, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04453-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

MAPK/ERK signaling enhances glioma immunotherapy via increased T cell infiltration an… PMID:42350396, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74124-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cisplatin induces neurotoxicity by activating NER in neurons, leading to cell death instead of protection. Insights challenge traditional views on DNA repair mechanisms. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel EMF-responsive gene switch enables precise in vivo control of gene expression, revealing Cyb5b's role as an EMF sensor via CRISPR-Cas9 screening. PMID:41985457, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00330-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 311 brain samples reveals >1,000 somatic cancer variants in Alzheimer's microglia. These drive clonal expansion and inflammation, spotlighting links to cancer. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research using SAMENT highlights that metastatic niches show 50% macrophage enrichment and 30% T cell depletion, revealing organ-specific features in bone metastasis. PMID:42054994, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00398-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Wang et al. unveil RegVelo, a game-changing framework linking gene regulatory networks to RNA velocity, identifying key regulators influencing cell fate changes. PMID:42276033, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600588X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Replayed 100+ monoclonal GC reactions to quantify antibody evolution. Deep mutational scanning reveals key dynamics in B cell affinity competition. #ScienceInsights PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Teclistamab + daratumumab show promise in NDMM in phase 2. Initial results: deep responses but ongoing; watch for data! PMID:42350642, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04471-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The best rates for #ASHG26 close TODAY at 5 PM U.S. ET. Secure your spot before rates increase and join the researchers, clinicians, and industry professionals shaping the future of human genetics and genomics in Montréal: https://bit.ly/4o3wfxM #ASHG #HumanGenetics

Frequent prion-based switching of DNA repair proteins boosts mutagenesis in S. cerevisiae, enhancing adaptive evolution across diverse environments. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Autoantibodies identified in ~25% of long COVID patients may drive symptoms like pain, fatigue, and cognitive issues, highlighting the disease's complexity. PMID:42208496, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00511-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New cryo-EM structures reveal the 2:4:2 assembly of Wnt3a/Fzd8/LRP6 complexes, showing how Wnt3a homodimers engage Fzd and LRP6 for Wnt/β-catenin signaling! PMID:42202788, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00523-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Variant in situ sequencing (VIS-seq) reveals phenotypic impacts of ~3,000 LMNA and PTEN mutations, highlighting protein changes and cell architecture critical for disease study. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG 🧪

Neuronal state influences expression of psychiatric gene variants. A crucial piece for understanding mental health! 📘🧠 PMID:42348709, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.aei6085 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪