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Grilled Cheese is a product of Village Compute

Version devBuilt at: 2026-10-16 08:00:47 EDT

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Comparative schematic of the CYP6AE19–UGT33 detoxification cascade mediating xanthotoxin metabolism in H. armigera and H. assulta. In H. armigera, dietary xanthotoxin is efficiently metabolised through a sequential Phase I–Phase II pathway. CYP6AE19 first catalyses O-dealkylation to produce xanthotoxol or aromatic-ring hydroxylation to generate 5-hydroxyxanthotoxin. These hydroxyl-containing intermediates are then glucosylated by UGT33 enzymes to form xanthotoxol glucoside and 5-hydroxyxanthotoxin glucoside, thereby increasing their hydrophilicity and promoting detoxification. In H. assulta, HsCYP6AE19 lacks detectable activity towards xanthotoxin, and only a subset of HsUGT33 enzymes show weak glucosylation activity towards xanthotoxol and 5-hydroxyxanthotoxin, indicating attenuation of this coordinated P450–UGT detoxification cascade.
This is the cover of the book Tsunami: Women’s Voices from Mexico. The background art features a red colored abstract line pattern, over shades of purple, with green in the lower left. The book title is in large, bright yellow type across the center. The top left text says that the book is edited by Gabriela Jauregui and Heather Cleary.
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Two versions of the same results slide from an illustrative heart failure trial with synthetic data. Before: a blue header reading "Results – Primary Outcome (90-Day Readmission)", seven dense bullet points of statistics, a 3D bar chart comparing 30-day and 90-day readmission in two groups, and a red box reading "p = 0.009!". After: the headline "One pharmacist review cut 90-day readmission from 33.7% to 23.5%", a flat two-bar chart of 90-day readmission with error bars, and three large numbers beside it: absolute risk difference −10.2 percentage points, risk ratio 0.70, and number needed to review 10, each with its 95% confidence interval.
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I am writing to let you know that, unfortunately, your application was not successful. Review process As part of the initial triage of the 179 proposals submitted to this call, each was assessed using an AI-based review. Every proposal was read independently by several different AI models against the same seven criteria used to shape this call (including cyber security relevance, research quality and novelty, importance of the problem addressed, feasibility of the project plan, likely outputs and impact, value for money, and responsible research practice), with each model asked to give a score and a written justification with supporting quotations from the text. To guard against any one model's idiosyncrasies, we also ran a second, independent process in which different AI models debated the merits and weaknesses of each proposal before reaching a judgement, again against the same criteria. Scores from both processes were combined to produce an overall ranking. This AI-based triage was used only to identify approximately 50% of the strongest proposals to take forward to full human review. Projects selected for funding were drawn from those that progressed to the full human review stage. We recognise that AI-assisted assessment is a new and evolving part of the review process, and we are continuing to evaluate how well it aligns with the judgements of human reviewers on this call. We will soon produce a document detailing our method, so that others can build upon it and improve it. Feedback on your application Your application was not selected to progress beyond the AI triage stage. To provide transparency on the outcome of this assessment, we are sharing below the scores (out of 5) from each of the two AI review processes described above, together with the mean score across the two processes.
Male wild type guppies. Image credit Wouter van der Bijl.
Computer Science and Mathematics  -   Artificial Intelligence and Machine Learning Refusal as a Broken Symmetry: Mechanistic Interpretability of Output-Policy Capture Across Jailbreak, Hypnosis, and Vaśīkaraṇa Sharath Sathish *
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A person in a green suit tumbling through the air with their laptop, computer mouse, coffee, and notebooks. On the left, a white dog with brown splotches across it's back and ears jumps for a red bone.
A compilation of web pages for four news broadcast channels: CNN, CBS News, ABC News and Fox News.
Open faculty positions in Bar Harbor are announced with an invitation to apply and join at JAX, featuring The Jackson Laboratory logo on a blue gradient background.
The inaugural class of Sacramento State’s Black Honors College poses with campus leaders at a ceremony.
WGS South Flyer showing the Statue of Liberty behind metal fencing. On the other side of the fence are silhouettes of various protestors. The text reads, "Fugitive Feminisms: Synchronize your calendars: March 11-13, 2027"
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