Exciting progress in DMD treatment: long-term reversal achieved via circ-arRNA-guided exon skipping in monkeys and humans, leveraging ADAR for effective RNA editing! #DMD PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 is crucial for safe human somatic cell reprogramming toward pluripotency, balancing genome stability with Yamanaka factors for effective cell fate manipulation. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 1,025 species reveals that early unicellular genomes were random; evolution led to structured "global folding" & "checkerboard" formations in complex life. PMID:42019492, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00343-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleoproteomic analysis of dental enamel from 23 H. naledi specimens (20 individuals) reveals no male markers, suggesting a possible single-sex population. Fascinating! PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

We’re hiring! Join our growing RNA research community at Indiana University Bloomington.

We are seeking an Assistant or Associate Professor in RNA Science and Technology. All area of RNA research are welcome.

Please repost! #RNA #RNAbiology #FacultyJobs

jobs.sciencecareers.org/job/680381/

Cisplatin, while effective against cancer, induces neuronal death via nucleotide excision repair (NER), which instead of protecting neurons, contributes to their vulnerability. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG 🧪

Single-cell mapping of DNA-protein interactions via D&D-seq reveals insights into transient TF bindings, enhancing understanding of gene regulation at single-cell resolution. PMID:42242226, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00573-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Pesquisadores da Universidade de Toronto criaram uma nova terapia com RNA de transferência modificado para tratar doenças genéticas como fibrose cística e distrofia muscular, superando mutações prejudiciais.

#rna #doencasgeneticas #terapia #pesquisa #universidadedetoronto

A new non-invasive genetic system reveals that brain protein clearance follows unique routes to CSF, uncovering drainage hotspots often missed by traditional tracers. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel experimental model reenacted 100+ monoclonal germinal center (GC) reactions, revealing insights into B cell competition and affinity maturation dynamics. PMID:42248140, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00572-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New findings reveal that macrometastases in breast cancer activate a Metastatic Trabecular Morphogenesis (MTM) program, leveraging developmental pathways for expansion. PMID:41923644, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600276X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover life science tools with bio.tools: a registry offering easy access and metadata for 15K+ software solutions. ✨ Search smarter! PMID:42363751, Nucleic Acids Res 2026, @NAR_Open https://doi.org/10.1093/nar/gkag420 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive mechanosensation via PIEZO1 in bladder epithelial cells drives nociceptive innervation & chronic pain after repeated E. coli infections, linked to IL-6. PMID:42361796, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00649-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Unlocking genome regulation: A new method analyzes over 1.6M compositions, tests 653, & finds a buffer boosting mRNA by 20x for clearer gene expression insights. PMID:42364991, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74559-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A model reveals that geometric constraints significantly shape mammalian cortical connectomes, highlighting 3D connectivity's role in their complex architecture. PMID:42361798, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00648-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals hippocampal neurons link bilingual semantics—finding "cross-language neurons" responding similarly to words like "tierra" (spanish) and "earth" (english). PMID:42341760, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00579-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

50% of fertilized eggs stall in human pre-implantation. Imaging 150+ embryos shows the 2nd mitotic division has the highest errors. PLK4 inhibition can reduce centriole overduplication. PMID:42276044, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00637-9 #Medsky #Pharmsky #RNA 🧪

#高校の生物基礎を勉強するための動画

映像授業Try ITシリーズ
「#生物基礎」 35/135

#遺伝子 7
#RNA について （１３分）
https://www.youtube.com/watch?...

#生物 #高校生物
#生命 #生命科学

New study reveals CD8+ T cell immunity enhances tumor sensitivity to cuproptosis, suggesting a link between copper-induced cell death and improved immunotherapy outcomes. PMID:42330950, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00636-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Prion-based protein self-assembly enables rapid adaptive mutagenesis in Saccharomyces cerevisiae populations, altering DNA repair mechanisms for evolution. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪