Aging male mice show disrupted water balance/thermoregulation: AVP neurons in hypothalamus are key. RNA-seq finds Avp upregulated. Old neurons enlarged, more excitable. PMID:42364986, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74819-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A variant (rs17437411) in the HOXA locus lowers blood counts, protects against blood cancers, and alters phenotypes, linked to a new lncRNA, HOXA opposi. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Excessive vascular integrity in small-cell lung cancer leads to immune desertification. Wang et al. propose "reverse normalization" to enhance immunotherapy efficacy. PMID:42349379, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00634-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research shows heat stress in mice elevates KLK14, leading to metabolic dysfunction on an obesogenic diet. Heat stress affects 1 in 3 mice’s metabolic health! PMID:42019490, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00346-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host gut metabolism using its Bacteroides fragilis toxin, fostering an oxidative environment that promotes its growth amid inflammation. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cryo-EM reveals VPS13A's complex with scramblase XK, highlighting their roles in vesicle-independent lipid transfer across organelle contact sites. Insightful collaboration! PMID:42285089, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00586-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Engineered ADAR-recruiting RNAs (arRNAs) boost RNA editing by leveraging endogenous ADAR, with LEAPER 3.0 enhancing precision via AlphaFold 3 insights. PMID:42269608, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00514-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A variant (rs17437411) in the HOXA gene locus links to reduced blood counts, cancer protection, and impacts on human hematopoietic stem cells via a novel lncRNA, HOXA opposi. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Largest proteogenomic study (n=78,664) reveals >24,000 protein QTLs linked to 1,116 proteins, uncovering pathways and genetic effects on disease mechanisms. PMID:42097137, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00385-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study links autoantibodies (AABs) to neurological symptoms in long COVID, revealing AABs against CNS and PNS proteins in patients—suggesting a causal role. PMID:42208499, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600509X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Enterotoxigenic Bacteroides fragilis (ETBF) rewires host metabolism using its toxin to thrive in the inflamed gut, revealing potential targets for colitis and cancer prevention. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG 🧪

THE COUNTDOWN IS ON!!
2026 PUTT Virtual Summit
TOMORROW September 23rd
10 am ET / 9 am CT

Because #PBMs aren't gonna follow the law on their own

Don't Miss Out!
Register Now👉 bit.ly/4gSzpCO

#PUTTSummit2026 #PatientsBeforeMonopolies #PharmacistsFightBack #PharmSky #MedSky

Autoantibodies against type-I interferons (AAN-I-IFNs) are key in severe viral infections like life-threatening COVID-19, revealing diverse B cell responses even before severe symptoms. PMID:42097138, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00438-1 #Medsky #Pharmsky #RNA 🧪

A novel method, VIS-seq, measures diverse phenotypic effects of ~3,000 LMNA & PTEN variants, revealing complex impacts on protein activity and cell structure. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel non-invasive genetic system reveals unique drainage routes for neuron-derived proteins from the brain to CSF, uncovering overlooked clearance hotspots. PMID:42214342, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00515-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Respiratory Folk

New AIR/MART inhaler measure to monitor the impact of the changes introduced in the BTS/NICE/SIGN asthma guideline across English general practices and hospitals

Audit your organisations progress!

www.bennett.ox.ac.uk/blog/2026/09...
#medsky #pharmsky

Cisplatin, a cancer treatment, induces neurotoxicity. NER helps neurons remove DNA damage but paradoxically leads to cell death. Understanding this may aid neuroprotection. PMID:42269607, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00584-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Cysteine's sulfur directs CD8⁺ T cell metabolism, splitting between glutathione and iron-sulfur clusters, fueling 3 key processes: proliferation, function, and 2x anti-tumor immunity! PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA 🧪

Large models like GPT-5 & Gemini show promise in health AI but can falter under simple stress tests, revealing key growth areas. PMID:42362863, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04501-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Check out PlanarFold: a new RNA model boosting simulation speed by over 10,000x with 2D coarse-grained dynamics, offering insights into RNA structures & dynamics! PMID:42362537, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74729-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪