CMS introduces a payment model linking AI-driven behavioral health care to outcomes, potentially revolutionizing care delivery. PMID:42340690, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1681 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/veg revealed garlic as a top choice for deterring mating & egg-laying in Drosophila. Diallyl disulfide is the key compound! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

10-year study: CAR T-cell therapy, CTL019, shows promise for relapsed B-cell lymphomas in 38 patients (24 large, 14 follicular). Retweet for insights! PMID:42341302, N Engl J Med 2026, @NEJM https://doi.org/10.1056/NEJMoa2518035 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover: Streptomyces encodes a megacluster for synergistic antibiotics! New genetic insights into coordinated multi-metabolite systems. Nature's innovation at its finest. PMID:42343126, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10647-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Frequent prion-based switching of DNA repair proteins boosts mutagenesis rates in S. cerevisiae, enhancing rapid adaptation across diverse environments. PMID:42263676, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00577-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough in gene control: An EMF-inducible gene switch enables precise in vivo gene expression activation via Cyb5b, revealed through CRISPR-Cas9 screening! PMID:41985457, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00330-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study reveals >1,000x sequencing of 311 AD brain samples shows cancer driver sSNVs in microglia-like cells, linking clonal hematopoiesis to neuroinflammation. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Developed SPAC-seq and TARDIS, enabling high-throughput spatial CRISPR screens. Achieved insights into gene perturbations, linking 100+ genes to spatial phenotypes! PMID:42190664, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00516-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Randomized trial (N=300) finds online team-based care for AD matches in-person treatment in reducing disease severity across 8 clinics! 🤝✨ PMID:42340708, JAMA Dermatol 2026 https://doi.org/10.1001/jamadermatol.2026.1959 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study decodes 60,803 spectra from 1,000+ samples uncovering 8,746 unique protein substitutions in humans, shedding light on translational deviations. PMID:42343131, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10678-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough in rare disease diagnostics! Talos: automated genomic reanalysis tool boosts diagnostic yields with precision. Open-source & scalable. #Genomics PMID:42343115, Nat Med 2026, @NatureMedicine @broadinstitute https://doi.org/10.1038/s41591-026-04477-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

B cells enhance exercise capacity by secreting TGF-β1, which reprograms hepatic glutamine metabolism via GLS2 and SLC7A5, preserving muscle glutamate for ATP production! PMID:42208497, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00513-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Discover how PUS1 and mtIF2 drive assembly of human mitoribosomal small subunits, crucial for mitochondrial translation, vital for cell energy—key to tackling diseases! PMID:42342677, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74700-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Explore STING's mutational impact on immunity, revealing interplay of structural changes, interactions, and trafficking crucial for host defense and inflammation. PMID:42343134, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10685-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New Nature study uncovers small molecules directly modulating β-arrestins, key players in GPCR signaling. A leap forward in therapeutics! PMID:42343124, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10683-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

GLP-1 receptor agonists are used by 34% of people with eating disorders; misuse found in 12%. Discuss the implications! PMID:42340738, JAMA Psychiatry 2026, @JAMAPsych https://doi.org/10.1001/jamapsychiatry.2026.1716 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A new deep learning framework, Deep-Phase, links biomolecular condensate morphology to biochemical alterations, revealing how drugs affect cellular organization. #Biomedicine PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RGS22 is crucial for metazoa-specific ciliary function. Mouse Rgs22 deficiency disrupts cilia coordination. This evolution aspect is key for tissue-wide flow! PMID:42342706, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74801-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Polyploidy drives evolution in angiosperms but is rarely ancient. A study of 470 species identified 132 dated WGD events, revealing non-random clustering patterns. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal that p53 is crucial in regulating human somatic cell reprogramming, balancing efficiency and safety amid potential oncogenic risks. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪