Paleoproteomic analysis of dental enamel from 23 H. naledi specimens reveals no male markers, suggesting a sample population from a single sex. #HomoNaledi #Paleoproteomics PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Anopheles stephensi, an urban malaria threat to 126M Africans, originated from a South Asian strain to Djibouti, as shown in 645 genomes. PMID:42348676, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adx6925 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Aging disrupts tissue homeostasis via mesenchymal drift, where cells lose lineage identity and gain mesenchymal traits, integrating and amplifying the hallmarks of aging. PMID:42208498, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00455-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Learning reshapes the neural geometry of the primate PFC, evolving from exploring diverse rules to efficiently encoding task-relevant info. PMID:42350815, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02333-w #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Metabolomics and metagenomics of 4,336 plasma samples from 1,714 cancer patients reveal metabolic determinants for immune-checkpoint inhibitor outcomes! PMID:42350644, Nat Med 2026, @NatureMedicine https://doi.org/10.1038/s41591-026-04481-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study shows clade Ia monkeypox virus spreads efficiently through sexual contact. Investigates shedding and transmission in prairie dogs. Key data for outbreak control! PMID:42350436, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74578-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Orofacial clefts (OFCs) are common, yet their origins remain complex & highly varied. @hggadvances.bsky.social latest study identifies subtype-specific genetic associations in cleft lip, highlighting the importance of in-depth characterization of OFC subtypes: https://bit.ly/4hds282 #ASHG

12 cave lion genomes (over 100,000 years old) reveal modern and cave lions as distinct lineages with unique traits and ancient gene flow between them. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The authors of @ajhgnews.bsky.social latest article show that a common lupus risk haplotype enhances IRF7 nuclear localization, DNA binding, and type I interferon production. Their findings reveal an evolutionary trade-off between host protection and autoimmunity: https://bit.ly/4xkoJld #ASHG

Discover: Ginseng's embryonic protoderm efficiently produces ginsenosides, overcoming long growth cycles. Single-cell transcriptome shows high accumulation, boosting potential. PMID:42350386, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74881-5 #Medsky #Pharmsky #RNA #ASHG 🧪

Human hippocampal ripples adjust cortical responses based on predicted uncertainty, optimizing brain info encoding. PMID:42350816, Nat Neurosci 2026, @NatureNeuro https://doi.org/10.1038/s41593-026-02345-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies TMEM154/Galvanin as a key receptor that allows cells to sense electric fields, guiding movement toward the cathode. #CellMigration #Therapeutics PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel CRISPR-Cas9 mouse library targeting 84 host factors revolutionizes influenza research, enabling in vivo validation and deeper insights into viral pathogenesis! PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Breakthrough: Cryo-EM reveals structures of human LWS-, MWS-, and SWS-opsins with G protein, decades after rhodopsin. Stunning insights! PMID:42348690, Science 2026, @ScienceMagazine https://doi.org/10.1126/science.adz8141 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits & veggies found garlic effective against mating & egg laying in Drosophila. Diallyl disulfide deters both behaviors! 🧄🐞✨ PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Small cell lung cancer (SCLC) features a unique blood-brain barrier-like vascular gate that limits immune cell infiltration, explaining poor immunotherapy responses. PMID:42102817, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00452-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

AI enhances CAR T therapy by identifying GPNMB as a promising target in melanoma (up to 50% response), leukemia, and colorectal cancer, streamlining target selection. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Lariat RNA debranching by DBR1 enzyme prevents 21- & 22-nt lasiRNA production, avoiding… PMID:42348705, Science 2026, @ScienceMagazine @OTSociety @NAR_Open https://doi.org/10.1126/science.aeb4938 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights reveal that microtubule-associated protein 1B (MAP1B) shuttles to the nucleus of neural stem cells, suggesting its role in cell fate and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A breakthrough study maps 379 cell types in whole-mouse sections using spatiotranscriptomics, analyzing 59M single cells for precise histological insights! PMID:41903540, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00273-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪