A study on NSCs reveals that MAP1B, a microtubule-associated protein, shuttles to the nucleus, linking cytoskeletal dynamics to transcriptional regulation and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Engineered GMPs enable long-term expansion of mouse and human progenitors for tumor immunotherapy, powered by myeloperoxidase's role in proliferation. Transformative! PMID:42320470, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00643-4 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel pooled imaging method, VIS-seq, analyzed ~3,000 LMNA & PTEN variants, uncovering high-dimensional phenotypic profiles linked to protein behavior and cell structure. PMID:42127894, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00466-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ETBF rewires host metabolism via its virulence factor to thrive in the inflamed gut, fueling oxidative growth in the large intestine and linking to colitis & CRC. PMID:42066751, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00401-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

🧬 RNA m5C in cancer: ready for the clinic?
🔬 A new review in LabMed Discovery examines the measurement gap.
🎯 Key insights: assay limitations, reliable quantification & a roadmap to clinical validation.
🔗 doi.org/10.1016/j.lm...
#RNA #CancerBiomarkers

Cells can detect and navigate electrical fields via the receptor TMEM154/Galvanin, guiding movement toward the cathode. A breakthrough in cell migration studies! PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

RegVelo merges gene regulatory dynamics with RNA velocity, enabling deeper insights into cell fate transitions by modeling splicing kinetics and GRN interactions. PMID:42119563, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00457-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

ERDRP-0519, a non-nucleoside polymerase inhibitor, shows strong inhibition of Measles (MeV) and weaker effects on Nipah virus (NiV). It binds to a conserved pocket in RNA-dependent RNA polymerase, with… PMID:42061399, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00400-9 #RNA 🧪

A phytoscreen of 43 fruits identified garlic as a strong mating & egg-laying deterrent in Drosophila, with diallyl disulfide inhibiting these behaviors. Fascinating! PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New insights on polyploidy reveal 132 ancient whole-genome duplications across 470 angiosperm species, showcasing non-random clustering during environmental upheaval. PMID:42105759, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00397-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New trimodal platform combines in vivo Ca²+ imaging, single-neuron morphology, and transcriptomics, enabling comprehensive insights into neuronal functions! PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New study identifies MARCH7 as a key E3 ligase that suppresses ferroptosis by regulating Fe²⁺ levels via K48-linked ubiquitylation of NCOA4, offering potential for ferroptosis-targeted therapies. PMID:42049018, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00388-0 #Medsky #RNA 🧪

🧬 Small molecules. Bigger possibilities.
Explore the next wave of oligonucleotide therapeutics, RNA medicines, and innovative delivery technologies at OTDC 2027.

📅 May 11–12, 2027 | 📍 Boston, MA & Virtual
🔗 oligo-nucleotide.com
#OTDC2027 #RNA #Oligonucleotides #DrugDelivery

Innovative Deep-Phase uses neural networks to analyze condensate morphology via microscopy, linking molecular interactions to drug-induced changes in 10+ condensate types. Transformative for cell biology! PMID:42242225, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00569-6 #RNA 🧪

A study reveals variant rs17437411 in the HOXA locus links to lower blood counts & cancer protection, disrupting a novel lncRNA (HOXA opposi), influencing hematopoietic stem cells. PMID:42068976, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00439-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Exciting progress in DMD treatment: long-term reversal achieved via circ-arRNA-guided exon skipping in monkeys and humans, leveraging ADAR for effective RNA editing! #DMD PMID:42269605, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00589-1 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

p53 is crucial for safe human somatic cell reprogramming toward pluripotency, balancing genome stability with Yamanaka factors for effective cell fate manipulation. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Study of 1,025 species reveals that early unicellular genomes were random; evolution led to structured "global folding" & "checkerboard" formations in complex life. PMID:42019492, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00343-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleoproteomic analysis of dental enamel from 23 H. naledi specimens (20 individuals) reveals no male markers, suggesting a possible single-sex population. Fascinating! PMID:42341758, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00644-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

We’re hiring! Join our growing RNA research community at Indiana University Bloomington.

We are seeking an Assistant or Associate Professor in RNA Science and Technology. All area of RNA research are welcome.

Please repost! #RNA #RNAbiology #FacultyJobs

jobs.sciencecareers.org/job/680381/