A novel library of 84 CRISPR-Cas9 mouse lines enables in vivo screening of host factors in influenza A research, overcoming bottlenecks in functional validation. PMID:42302780, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600591X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Recent findings reveal that MAP1B, a microtubule-associated protein, shuttles to the nucleus in neural stem cells, linking cytoskeletal dynamics to gene regulation and disease. PMID:42276043, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00578-7 #Medsky #Pharmsky #RNA #ASHG 🧪

Cysteine's sulfur is crucial for CD8⁺ T cell fate, driving 60% toward glutathione and 40% for iron-sulfur clusters, influencing proliferation and anti-tumor immunity. PMID:42276031, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00570-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Paleogenomic analysis of 12 cave lion genomes from over 100,000 years reveals distinct evolutionary paths from modern lions, highlighting unique variants and evidence of ancient gene flow. PMID:42235515, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00524-6 #Medsky #Pharmsky 🧪

AI-driven discovery identifies GPNMB CAR T cells as a promising multi-cancer therapy, refining targets through single-cell RNA seq from 100+ datasets. Exciting advancements ahead! PMID:42349383, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00651-3 #Medsky #Pharmsky #RNA #ASHG 🧪

Exploring SMVT with cryo-EM: 3 structures unveiled—occluded, outward-open, inward-open—reveal how it transports vital vitamins. Key to tackling its dysfunction! PMID:42364996, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74948-3 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

NAD+ modulates mitochondrial vulnerability in MERTK models of retinitis pigmentosa (R… PMID:42365006, Nat Commun 2026, @NatureComms @OTSociety @NAR_Open https://doi.org/10.1038/s41467-026-74400-6 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Major breakthrough in HIV research: CRISPR screens in primary CD4+ T cells identified multiple pro- and anti-HIV host factors, revealing diverse antiviral mechanisms! PMID:42013838, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600382X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Chloroplasts use MBS1 to sense singlet oxygen (¹O₂) and trigger photoprotection, revealing how plants manage high-light tolerance through protein condensates. PMID:42309053, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00642-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A phytoscreen of 43 fruits/veggies reveals garlic as a potent inhibitor of mating & egg-laying in Drosophila. Diallyl disulfide shows promise in pest control! 🧄✨ PMID:41999745, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00338-7 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Don't miss out on tomorrow's webinar, which will highlight emerging opportunities to identify and exploit cancer-specific vulnerabilities, advancing the development of innovative precision therapies.

Register here: https://ow.ly/maw750ZPE9T
#pharmsky 🧪

Don't miss out on tomorrow's webinar, which will highlight emerging opportunities to identify and exploit cancer-specific vulnerabilities, advancing the development of innovative precision therapies.

Register here: https://ow.ly/maw750ZPE9T
#pharmsky 🧪

A study of 311 AD brains found somatic single-nucleotide variants (sSNVs) enriched in cancer driver genes, linked to clonal hematopoiesis and microglia-like cells, driving inflammation. PMID:42019491, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00341-7 #Medsky #Pharmsky #RNA 🧪

Intranasal boost in female mice primed with Wuhan-1 spike mRNA or ChAd vaccines enhances variant-specific antibodies, addressing immunity evasion in emerging SARS-CoV-2 variants. PMID:42364994, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74762-x #Medsky #Pharmsky #RNA #ASHG 🧪

CANVAS, an AI platform, analyzes 18M+ cells in H&E histopathology to reveal spatial tumor microenvironment insights, enhancing understanding of TME's role in disease and therapy resistance. PMID:42302781, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00590-8 #Medsky #Pharmsky 🧪

Revolutionizing neuroscience, a new trimodal platform reveals Ca²⁺ dynamics, morphology, and gene expression in single neurons for enhanced understanding of neuronal functions. PMID:42314668, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00641-0 #Medsky #Pharmsky #RNA #ASHG 🧪

Chronic suppression of MDR Pseudomonas aeruginosa in a prosthetic joint infection achieved via personalized bacteriophage treatment after antibiotics failed! PMID:42364990, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74326-z #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

A novel LLM-assisted scoring framework identifies GPNMB as a promising CAR T target in melanoma, leukemia, and colorectal cancer, addressing a key bottleneck in therapy. PMID:42349381, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00652-5 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

New research identifies TMEM154/Galvanin as a key receptor enabling cells to sense electric fields (≤ 100 mV/mm) and migrate toward the cathode. Exciting times! PMID:42349380, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00638-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Revolutionizing spermatogenesis studies, 2,653 genes in 867,062 mouse testis cells reveal dynamic cycles in Sertoli cells, aligning transcription with germ-cell differentiation. PMID:42143021, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S009286742600471X #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪